THE CORRELATION BETWEEN ^(13)C CHEMICAL SHIFTS OF DNA AND INTERSTRAND PURINE-PURINE CLASH  

作　　者：张友杰 王可玉 P.N.BORER G.C.LEVY 

机构地区：[1]Centre for Analysis and Testing, Central China Normal University, Wuchang 430070, PRC [2]NMR and Data Processing Laboratory, Syracuse University,Syracuse,NY 13244-4100, USA

出　　处：《Science China Chemistry》1992年第12期1416-1424,共9页中国科学（化学英文版）

摘　　要：The correlation between ^(13)C chemical shifts of DNA and structure parameters (the mainaxis helix twist angle Ω, base--plane roll angle ρ, main chain torsion angle δ and pro-peller twist angle ω) has been discovered and proved indirectly. The carbons relating tothe structure parameters have been found and interpreted theoretically. Relative variationsin chemical shifts of these carbons obviously reflect purine-purine clash (steric hindrance)and have been compared with sum functions Σ of Calladine--Dickerson rules. It would bepossible to provide the information about conformation of DNA from ^(13)C NMR spectra andto observe the structure parameters of Ω,ρ,δ and ω of DNA in solution.The correlation between ¹³C chemical shifts of DNA and structure parameters （the mainaxis helix twist angle Ω, base--plane roll angle ρ, main chain torsion angle δ and pro-peller twist angle ω） has been discovered and proved indirectly. The carbons relating tothe structure parameters have been found and interpreted theoretically. Relative variationsin chemical shifts of these carbons obviously reflect purine-purine clash （steric hindrance）and have been compared with sum functions Σ of Calladine--Dickerson rules. It would bepossible to provide the information about conformation of DNA from ¹³C NMR spectra andto observe the structure parameters of Ω,ρ,δ and ω of DNA in solution.

关 键 词：DNA ^(13)C NMR purine-purine clash Calladine-Dickerson rules 

分 类 号：O6[理学—化学]