STUDIES ON MACROCYCLIC DITERPENOIDS (Ⅲ)——TOTAL SYNTHESIS OF CEMBRENE-C  

作　　者：毛建民 李瀛 侯自杰 李裕林 梁晓天 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry, Institute of Organic Chemistry, Lanzhou University, Lanzhou 730000, PRG [2]Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, PRC

出　　处：《Science China Chemistry》1992年第3期257-261,共5页中国科学（化学英文版）

基　　金：Project supported by the National Natural Science Foundation of China and by the Special Research Grant for Doctoral Sites in Universities

摘　　要：Naturally occurring cembrene-C (1) has been synthesized from geraniol. The key steps were coupling reaction of the sulphone (6) and chloride (8) and selective cyclization of dicarbonyl compound (12) catalyzed by low valent titanium.Naturally occurring cembrene-C (1) has been synthesized from geraniol. The key steps were coupling reaction of the sulphone (6) and chloride (8) and selective cyclization of dicarbonyl compound (12) catalyzed by low valent titanium.

关 键 词：SYNTHESIS macrocyclic diterpene cembrene-C (E E E E)-1 7 1 1-trimethy1-4-isopropy1-1 3 7 11-cyclotetradecatetraene. 

分 类 号：O6[理学—化学]