POTENTIATED EFFECT OF VAGAL STIMULATION AND HORMONAL AGENTS ON PANCREATIC EXOCRINE SECRETION IN DOGS  

作　　者：梅懋华 

机构地区：[1]Department of Physiology, Dalian Medical College, Dalian 116023, PRC

出　　处：《Science China Chemistry》1991年第6期683-690,共8页中国科学（化学英文版）

基　　金：Study supported by the Chinese Academy of Sciences Grant (84) 246.

摘　　要：Chronic experiments were made on eighteen dogs with Thomas pancreatic fistula andgastric fistula. Both in chronic and acute experiments the degenerated right cervical vagusnerve was stimulated by electrical shock and the endogenous secretin and CCK was releasedby means of duodenal acidification (D. A.). The exogenous secretin, atropine and lidocainewere infused to analyse the interrelationship of neurohormones in the pancreatic exocrinesecretion. The results were as follows. In chronic experiments the pancreatic secretory la-tency was shorter and volume larger than that in acute experiments induced by D. A. Thedifference is very significant (P<0.001). Both vagotomy and atropine significantly inhibitedpancreatic secretion induced by D. A. (P<0.01). Lidocaine infused into duodenum inhibitedpancreatic secretion induced by D. A. as well. When vagal stimulation was combined withD. A., either simultaneously or successively, the pancreatic secretion was increased morethan the additive sum obtained by separate action of vagal stimulation and D. A. or secretin.In view of the above--mentioned facts, the author suggests that vagal impulses combined withD. A. or secretin act on the pancreatic exocrine secretion, and that the interaction of nerveand hormones appear to be mutually potentiated.Chronic experiments were made on eighteen dogs with Thomas pancreatic fistula andgastric fistula. Both in chronic and acute experiments the degenerated right cervical vagusnerve was stimulated by electrical shock and the endogenous secretin and CCK was releasedby means of duodenal acidification (D. A.). The exogenous secretin, atropine and lidocainewere infused to analyse the interrelationship of neurohormones in the pancreatic exocrinesecretion. The results were as follows. In chronic experiments the pancreatic secretory la-tency was shorter and volume larger than that in acute experiments induced by D. A. Thedifference is very significant (P&lt;0.001). Both vagotomy and atropine significantly inhibitedpancreatic secretion induced by D. A. (P&lt;0.01). Lidocaine infused into duodenum inhibitedpancreatic secretion induced by D. A. as well. When vagal stimulation was combined withD. A., either simultaneously or successively, the pancreatic secretion was increased morethan the additive sum obtained by

关 键 词：pancreatic EXOCRINE secretion VAGAL stimulation DUODENAL acidification ATROPINE LIDOCAINE 

分 类 号：O6[理学—化学]