Identification of 1-hydroxypyrene in urine of dogs after pyrene injection and its excretion  

作　　者：Zhao Zhenhua and Quan WenyiBeijing Municipal Research Institute of Environmental Protetion,Beijing 100037,China 

出　　处：《Journal of Environmental Sciences》1991年第2期127-132,共6页环境科学学报（英文版）

基　　金：This project is funded by the National Natural Sciences Foundation of China, and partially supported by Beijing Municiple Environmental Protection Bureau.

摘　　要：With high performance liquid chromatograph and fluorospectrometry, 1-hydroxypyrene is identified as a metabolite of pyrene in the urine of dogs after intramuscular injection of pyrene. When three successive doses of 1,2 and 5 μmol/kg wt. pyrene administered, urinary excretion of 1-hydroxypyrene reaches the peak level between 24th and 48th hours. Excreted 1-hydroxypyrene consists of only about 0.05% of injected pyrene.With high performance liquid chromatograph and fluorospectrometry, 1-hydroxypyrene is identified as a metabolite of pyrene in the urine of dogs after intramuscular injection of pyrene. When three successive doses of 1,2 and 5 μmol/kg wt. pyrene administered, urinary excretion of 1-hydroxypyrene reaches the peak level between 24th and 48th hours. Excreted 1-hydroxypyrene consists of only about 0.05% of injected pyrene.

关 键 词：1-HYDROXYPYRENE PYRENE polynuclear aromatic hydrocarbons. 

分 类 号：X[环境科学与工程]