Circular dichroism of tail-to-tail bisbenzylisoquinoline and the absolute configuration of daurisoline isolated from Menispermum dauricum  

作　　者：KONG,Rong-Zu KUANG,Dai-Wu HUA,Wei-Yi Department of Pharmaceutical Chemistry,China Pharmaceutical University,Nanjing 210009MIN,Zhi-Da ZHAO,Shou-Xun Department of Phytochemistry,China Pharmaceutical University,Nanjing 210009MIZUNO,Mizuo IINUMA,Munekazu TANAKA,Toshiyuki Department of Pharmacognosy,Gifu Pharmaceutical University,5-6-1 Mitahora-higashi,Gifu 502,Japan 

出　　处：《Chinese Journal of Chemistry》1991年第3期275-278,共0页中国化学（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China.

摘　　要：Since two asymmetric centres are usually present in the bisbenzylisoquinolines,the circular dichroism is known to be an important method to elucidate their stereochemistry.We studied the relationships of the CD spectra with the stereochemistry of synthetic RR-(1),SS-(2),RS-daurisoline(3) and SR-daurisoline(4).By comparision of the CD spectrum of natural daurisoline(1)from Menis- permum dauricum(Menispermaceae)with those of synthetic enantiomers,the absolute configuration was established as RR-daurisoline(1).Since two asymmetric centres are usually present in the bisbenzylisoquinolines,the circular dichroism is known to be an important method to elucidate their stereochemistry.We studied the relationships of the CD spectra with the stereochemistry of synthetic RR-(1),SS-(2),RS-daurisoline(3) and SR-daurisoline(4).By comparision of the CD spectrum of natural daurisoline(1)from Menis- permum dauricum(Menispermaceae)with those of synthetic enantiomers,the absolute configuration was established as RR-daurisoline(1).

关 键 词：RR RS CD Circular dichroism of tail-to-tail bisbenzylisoquinoline and the absolute configuration of daurisoline isolated from Menispermum dauricum 

分 类 号：O6[理学—化学]