甲型肝炎减毒活疫苗(L-A-1株)扩大人群的反应及效果观察  

The Reactogenicty and Efficacy of Live Attenuated Hepatitis A Vaccine

作　　者：王鹏赋[1] 王伟[1] 刘景晔[1] 贾悦[1] 郭建军[1] 赵克俭[1] 武文焕[1] 张曦 何静芳 孙碧芳 应蓓蓓 胡孟冬 黄相臣 孙连军 金泰山 隋昌龙 王丽娜 

机构地区：[1]卫生部长春生物制品研究所,长春130062 [2]上海市卫生防疫站,上海200031 [3]吉林市卫生防疫站 [4]吉林省和龙县卫生防疫站 [5]吉林省防病中心

出　　处：《中国生物制品学杂志》1991年第4期178-180,共3页Chinese Journal of Biologicals

摘　　要：为进一步研究甲肝减毒活疫苗的安全性及免疫原性,在小量人体观察(30名志愿者)获得满意结果的基础上,进行了扩大人群的再观察。选350名8～11岁健康学龄儿童,随机分成5个组,对不同接种剂量、不同接种途径及不同滴度的疫苗接种后的反应及效果进行了观察。结果表明,所有受试者均无局部和全身反应,亦无肝酶的异常升高。免后4周,不同剂量、不同途径的抗体阳转率为70～100%,免后8周为98～100%,进一步证实该实验性疫苗是安全的,其免疫原性是良好的。On the basis of satisfactory results in limited numbers of recipients(30volunt- eers),we observed an enlarged group of 350 healthy school children from age 8—11,who were randomly divided into 5 groups and injected with different doses,and titres by fiffer- ent routes with the experimental hepatitis A vaccine.The results showed that none of the recipients developed any local or systemic adverse reaction,and no abnormal elevation of body temperature or liver enzyme were found.The seroconversion rates at four weeks after immunization ranged from 70—100%,and 98—100% at 8 weeks.It suggested that the exper- imental vaccine was safe with good immunogenicity.

关 键 词：甲肝减毒活疫苗 接种反应 免疫效果 

分 类 号：R977[医药卫生—药品]