伤寒Vi荚膜多糖菌苗的研究  

Studies on Typhoid Vi Capsular Polyssacharide Vaccine

作　　者：沈玉霖 扈晶[1] 王秉瑞[1] 计国欣[2] 张河战[2] 辜清吾[2] 

机构地区：[1]卫生部兰州生物制品研究所,兰州730046 [2]中国药品生物制品检定所,北京100050

出　　处：《中国生物制品学杂志》1991年第1期5-8,共4页Chinese Journal of Biologicals

摘　　要：Robbins等人证实:用不变性方法提纯的伤寒沙门氏菌荚膜多糖(Vi抗原)不仅有抗原性,且对伤寒沙门氏毒菌攻击具有保护作用。我们用不变性方法提纯了Vi抗原并对其化学和生物学特性进行了检定,初步证实了Robbins Vi抗原具有保护作用的意见,用0.5～1.0μg提纯的Vi抗原免疫,对Vi^+的伤寒沙门氏毒菌菌株的攻击可提供高度防御作用。It was shown that the typhoid Vi capsular pol yssacharide vaccine purified with undenatured method was not only antigenic but also protective against the typhoid fever. We have tried to purify the Vi antigen using the procedure reported by Robbins et al with some modifications and tested the chemical and biological properties of it. The rsults were agreeable with the report by above mentioned authors. It showed that one does of 0.5～1.0μg typhoid Vi antigen could produce a high protection effect against the challenge with virulent salmonella typhi strain Ty2 in mice.

关 键 词：VI抗原 免疫力试验 

分 类 号：R977[医药卫生—药品]