胰管栓塞后胰岛B-细胞内分泌功能变化机理探讨  

The mechanisms of the changes in endocrine function of pancreatic islet B-cells after pancreatic duct obstruction

作　　者：李占京[1] 巢振南[1] 金锡礼 王慧贞[1] 田伏洲[1] 吕民生[1] 

机构地区：[1]成都军区总医院腹部外科

出　　处：《西南国防医药》1991年第1期4-6,共3页Medical Journal of National Defending Forces in Southwest China

摘　　要：对8只正常犬行α-氰基丙烯酸脂胰管栓塞术,术后3月对其中5只行胰腺组织学及超微结构观察,旨在探讨胰管栓塞后胰岛B-细胞内分泌功能减退之机理。光镜观察发现胰外分泌腺基本消失,纤维组织形成,间有炎细胞浸润,胰岛内纤维组织增生、水肿。电镜观察见胰岛内水肿,胶原纤维增生,B-细胞呈不同程度损害。结果表明,B-细胞绝对数量减少、残存B-细胞结构损伤和代谢障碍以及局部环境的改变系B-细胞内分泌功能减退的主要原因。Pancre atic duct obstruction (PDO) was performed with an a-cyanoacrylate glue in 8 healthy beagles. Pancreatic biopsies were taken in 5 of the animals. Biop sies were studied on histology and ultrastructure in order to reveal the mechanisms in the decrement of the endocrine function of pancreatic islet B-cells. The exocriae tissue was almost replaced by fibrodid with scattered inflammatory cells. Pancreatic islets were edematous and fibrosis. B-cells were damaged in different degrees. Our results show that the hypoinsulinisms are mainly due to the decrease of the number of the B-cells, the structural damages and metabolic disturbance of the residual B-cells, as well as the microenvironmen tdisorder in the pacreas islets.

关 键 词：胰管 胰岛 内分泌 组织学 超微结构 

分 类 号：R82[医药卫生—临床医学]