贝前列素钠联合阿托伐他汀治疗TIA合并颈动脉斑块的对照研究  

Control study of Beraprost Sodium and atorvastatin in treatment with TIA combined carotid plaques

作　　者：郑静红[1] 吴文君[1] 佘子瑜[1] 梁群娣[1] 潘军利[1] 

机构地区：[1]中山市人民医院神经内科,广东中山528403

出　　处：《中国生化药物杂志》2014年第1期125-126,129,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：中山市科技计划项目(20122A182)

摘　　要：目的探讨贝前列素钠联合阿托伐他汀治疗短暂性脑缺血发作(transient ischemic attack,TIA)合并颈动脉斑块的治疗效果。方法选择我院收治的60例TIA合并颈动脉斑块患者,随机分为观察组和对照组各30例,观察组接受贝前列素钠和阿托伐他汀钙治疗,对照组单用阿托伐他汀钙治疗,12个月后比较两组颈动脉斑块面积变化和凝血功能情况。结果观察组颈动脉斑块面积明显小于对照组,2组比较差异具有统计学意义(P<0.05);治疗后观察组血小板聚集率(platelet agglutination test,PAgT)、血浆纤维蛋白原(fibrinogen,Fg)、超敏C反应蛋白(hypersensitive 3 C—reaction protein,hsCRP)、总胆固醇(total cholesterol,TC)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL)、TIA复发率及缺血性脑卒中发生率与对照组比较均有统计学意义(P<0.05)。结论贝前列素钠联合阿托伐他汀在减小颈动脉斑块面积、调节血脂和预防TIA及缺血卒中发生方面具有良好的作用,值得临床推广应用。Objective To investigate the effect of Beraprost Sodium and atorvastatin in the treatment of TIA combined carotid plaques. Method 60 cases in our hospital with TIA and carotid artery plaques were randomly divided into observation group and control group, 30 cases in each group. The observation group was received beraprost natriuretic peptide and atorvastatin calcium therapy, the control group was treated with atorvastatin calcium. 12 months later,two groups were compared with carotid plaque area change and coagulation conditions. Results Carotid plaque area in observed group was significantly less than the control group (P<0.05). The differences of platelet agglutination test(PAgT), fibrinogen(Fg) , hypersensieive 3 C-reaction protein, total cholesterol(TC), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL), TIA recurrence rate and incidence of ischemic stroke between two groups after treatment were statistically significant (P<0.05). Conclusion Beraprost Sodium and atorvastatin has a good effect in reducing carotid plaques area, adjusting blood fat and preventing TIA and ischemic stroke, It is worthy to clinical popularization and application.

关 键 词：贝前列素钠 阿托伐他汀 短暂性脑缺血发作 颈动脉斑块 

分 类 号：R543.5[医药卫生—心血管疾病]