长期小剂量服用罗红霉素对支气管扩张症稳定期患者胸部CT影像学及临床症状改变的影响  

The effect of long term low dose roxithromycin on chest CT imaging and clinical symptoms change of bronchiectasis stable patients

作　　者：邱琦[1] 汤新慧[2] 鲍君杰[1] 潘杰[1] 朱亮[1] 

机构地区：[1]苏州大学附属第二医院药剂科,江苏苏州215000 [2]盐城师范学院生命科学与技术学院,江苏盐城224000

出　　处：《中国生化药物杂志》2014年第2期88-90,93,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：江苏省高校自然科学基金(07KJA18017)

摘　　要：目的：探讨长期服用小剂量罗红霉素治疗支气管扩张症稳定期患者的临床效果及肺部CT变化。方法选取2011年2月～2012年12月就诊于苏州大学附属第二医院呼吸科确诊的支气管扩张症患者94例，对照组34例，采用沐舒坦30 mg，3次/d，口服治疗。治疗组60例，在对照组基础上添加罗红霉素口服75 mg，2次/d。2组患者均治疗6个月。观察2组治疗效果及生活质量评分和呼吸困难评分，对比治疗前后CT数据变化。结果治疗后，2组生活质量评分和呼吸困难评分均有改善，但治疗组显著高于对照组（P＜0.05）；治疗后治疗组有效率为86.67%，对照组为70.59%，差异显著（P＜0.05）；治疗后治疗组患者胸部CT改善显著好于对照组，比较差异有统计学意义（P＜0.05）。结论长期小剂量服用罗红霉素治疗支气管扩张症症状控制稳定，体征改善明显。Objective To explore the clinical effect and lung CT change of long-term used of low-dose roxithromycin in treatment for bronchial expansion patients in stable phase. Methods 94 cases collected in the Department of Respiration, The Second Hospital Affiliated to Suzhou University from February 2011 to December 2012 were diagnosed as bronchiectasis, 34 cases in control group were given oral treatment for ambroxol 30 mg, three times one day, 60 cases in treatment group were added roxithromycin 75 mg on basis of control group, two times one day. Patients in two groups were both treated for 6 months. The therapeutic effect and the score of life quality and dyspnea scores in two groups were observed, and the changes of CT data were compared before and after treatment. Results After treatment, the life quality score and dyspnea score of two groups were all improved, but the treatment group was signiifcantly higher than the control group (P<0.05). The effective rate in treatment group was 86.67%, which was signiifcantly higher than 70.59%in the control group (P<0.05). After treatment, chest CT imaging score of patients in treatment group were improved, signiifcantly better than that in the control group (P<0.05). Conclusion Long-term low dose administration of roxithromycin can control and stable bronchiectasis symptoms, and improve signs and symptoms .

关 键 词：支气管扩张症 稳定期 罗红霉素 沐舒坦 CT影像学 

分 类 号：R816.4[医药卫生—放射医学]