人工全髋关节置换术中应用银杏达莫针对高血压老年患者的保护作用  

Protective effect of the application of Ginkgo-damole in elderly patients with hypertension in total hip arthroplasty

作　　者：任良[1] 王伟东[1] 王雪梅[2] 

机构地区：[1]余姚市人民医院外六病区,浙江余姚315400 [2]内蒙古医科大学第一附属医院骨科,内蒙古呼和浩特010050

出　　处：《中国生化药物杂志》2014年第3期81-83,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：2012年国家自然科学基金项目(81260224)

摘　　要：目的阐明人工髋关节置换术中应用银杏达莫针对高血压老年患者的保护作用。方法收集2012年1月到2013年12月67例行全髋关节置换术且合并高血压的老年患者,分为观察组(n=34)和对照组(n=33),对照组正常麻醉用药,观察组麻醉用药后,在术中使用银杏达莫注射液,观察2组患者麻醉效果以及收缩压(systolic blood pressure,SBP)、舒张压(dia blood pressure,DBP)、心率(heart rate,HR)和平均动脉压(mean arterial pressure,MAP)的变化,术后观察患者意识恢复时间。结果2组患者麻醉后的SBP、DBP、MAP和HR水平与麻醉前比较均有显著差异(P<0.05)。观察组在T_2、T_3、T_4时间点的SBP、DBP、MAP均明显高于对照组,HR水平低于对照组,差异具有统计学意义(P<0.05)。观察组在T_5时间点的SBP、DBP、MAP、HR均低于对照组,差异具有统计学意义(P<0.05)。观察组术后恢复时间低于对照组,2组相比有统计学差异(P<0.05)。结论人工全髋关节置换术中应用银杏达莫针能有效缓解麻醉和手术带来的不良应激反应,对高血压老年患者有保护作用。Objective To clarify protective effect of the application of Ginkgo-damole in elderly patients with hypertension in total hip arthroplasty.Methods From January 2012 to December 2013,67 elderly patients with hypertension which should take total hip arthroplasty were divided into observation group and control group.Ginkgo-damole were only used in observation group during the operation.The anesthetic effect and the change of systolic blood pressure(SBP)diastolic blood pressure(DBP),heart rate(HR)and mean arterial pressure(MAP)were observed,postoperative recovery time of consciousness were recorded. Results The level of SBP,DBP,MAP and HR in both group were significantly difference when compared with before anesthesia(P<0.05 ).At the T2-4 time point,the level of SBP,DBP,MAP in observation group were significantly higher than that of control group,the level of HR was significantly lower than the control group,there had significant difference(P<0.05).At the T5 time point,the level of SBP, DBP,MAP and HR in observation group were significantly lower than of control group,there had significant difference between two groups(P<0.05 ).The postoperative recovery time in observation group was(10.41 ±2.35)min,which was lower than that in control group(15.63 ±2.42)min,there had significant difference between two groups(P<0.05 ).Conclusion Ginkgo-damole can effectively relieve the stress reactions caused by anesthesia and total hip arthroplasty,it has good protective effect on elderly patients with hypertension.

关 键 词：人工髋关节置换术 老年 高血压 银杏达莫针 

分 类 号：R605[医药卫生—外科学]