氮卓斯汀、孟鲁司特钠配合左西替利嗪治疗慢性荨麻疹的临床研究  

Clinical study of azo steen,montelukast sodium combined with levocetirizine in treatment of chronic urticaria

作　　者：林利虹[1] 万慧[1] 李少波[1] 杜鹃[1] 

机构地区：[1]武汉大学医学院附属湖北省中山医院皮肤科,湖北武汉430033

出　　处：《中国生化药物杂志》2014年第3期148-150,153,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨氮卓斯汀、孟鲁司特钠配合左西替利嗪治疗慢性荨麻疹的临床疗效与价值。方法选取就诊于武汉大学医学院附属湖北省中山医院皮肤科的慢性荨麻疹患者150例,随机分为A组、B组、C组(n=50)。A组使用孟鲁司特钠联合左西替利嗪进行治疗;B组使用孟鲁司特钠联合氮卓斯汀治疗;C组联合3种药物治疗。比较3组治疗总有效率及不良反应、安全性等指标。结果疗效评价显示C组治疗总有效率显著高于A、B组(P<0.05),且C组安全评分指标也显著优于A、B组(P<0.05)。C组患者不良反应发生人数显著少于A、B组(P<0.05)。结论氮卓斯汀、孟鲁司特钠联合左西替利嗪共同治疗慢性荨麻疹疗效显著。能短时间内缓解患者瘙痒、风团等症状,不良反应较少。Objective To explore the clinical efficacy and value of azo steen,montelukast sodium combined with levocetirizine in the treatment of chronic urticaria. Methods 150 cases with chronic urticaria admitted in department of dermatology of Hubei Zhongshan Hospital were divided into A,B and C group,each group had 50 cases. Patients in group A were received montelukast sodium and levocetirizine treatment,which in group B were received montelukast sodium and azo steen treatment,group C were received above three kinds of drug treatment. Total effective rate,adverse reaction and safety in three groups were observed and compared. Results Total effective rate of group C was significantly higher than A and B group(P<0.05), and the safety of group C were better than A and B group(P<0.05 ),too. The occurrence of adverse reaction in group C was significantly less than that in group A and B (P <0.05 ).Conclusion Azo steen,montelukast sodium combined with levocetirizine has good efficacy in treatment of chronic urticaria. It can relieve itching wheals and other symptoms in a short time,with less adverse reaction.

关 键 词：氮卓斯汀 孟鲁司特钠 左西替利嗪 慢性荨麻疹 临床疗效 安全性 

分 类 号：R758[医药卫生—皮肤病学与性病学]