八正颗粒质量标准的改善研究  

Investigate the improvement of quality standard on eight-positive particles

作　　者：盛望鹏[1] 

机构地区：[1]海南科技职业学院生物与化工学院,海南海口571126

出　　处：《中国生化药物杂志》2014年第4期164-168,共5页Chinese Journal of Biochemical Pharmaceutics

基　　金：海南省自然科学基金(812186)

摘　　要：目的改进八正颗粒的含量测定法,更好地控制药品质量。方法运用高效液相色谱法对八正颗粒中栀子苷、大黄素和大黄酚含量进行测定,拟订含量测定标准,改进和完善质量控制标准。结果新修订的栀子苷、大黄素和大黄酚含量检测方法简单可行,且灵敏度高。结论统一了八正颗粒质量标准,为规范市场中八正颗粒的质量提供了依据。Objective To improve the content determination of eight-positive particles,and better control drug quality.Methods Gardenin, emodin and chrysophanol of eight-positive particles were determined by HPLC.Revised content determination standards and improved the standards of quality control. Results The revised content determinations of gardenin, emodin and chrysophanol were simple and feasible, and had high sensitivity.Conclusion Unification the quality standards of eight positive granules,the standards provide the basis for standardizing the market of eight-positive particles.

关 键 词：八正颗粒 栀子苷 大黄素 大黄酚 质量标准 

分 类 号：R283.6[医药卫生—中药学]