黄芪注射液联合阿苯达唑对华支睾吸虫病患者Th1/Th2细胞因子的影响研究  

Influence of Albendazole Combined with Astragalus Injection on Th1/Th2 Cytokines of Patients Infected with Clonorchis Sinensis

作　　者：袁金富[1] 袁杰 罗元[1] 廖云姣[1] 

机构地区：[1]荆楚理工学院医学院,湖北省荆门市448124 [2]从化市中心医院普外科

出　　处：《中国全科医学》2013年第27期3267-3269,共3页Chinese General Practice

摘　　要：目的探讨黄芪注射液联合阿苯达唑对华支睾吸虫引起肝损伤的保护作用及其对宿主Th1/Th2细胞因子的影响。方法选择2010年6月—2011年12月通过华支睾吸虫病粪检显示虫卵阳性且未经过任何治疗、除外其他肝病的华支睾吸虫病患者46例作为病例组,采用随机数字表法分为对照组和观察组,每组23例,另选择同期体检健康者23例作为正常组。对照组予阿苯达唑治疗,观察组予黄芪注射液联合阿苯达唑治疗,比较治疗前后血清丙氨酸氨基转移酶(ALT)、总胆红素(TBIL)、白介素2(IL-2)、白介素4(IL-4)、干扰素γ(IFN-γ)水平的变化,观察对照组和观察组的粪检虫卵转阴率及不良反应。结果治疗前3组ALT、TBIL、IL-2、IL-4和IFN-γ水平比较,差异均有统计学意义(P<0.05);对照组和观察组ALT、TBIL、IL-4水平较正常组升高,IL-2、IFN-γ水平较正常组降低,差异均有统计学意义(P<0.05)。治疗后观察组ALT、TBIL水平较对照组降低,IL-2、IFN-γ水平较对照组升高,差异均有统计学意义(P<0.05)。对照组与观察组虫卵转阴率〔91.3%(21/23)与100.0%(23/23)〕比较,差异无统计学意义(χ2=2.091,P>0.05)。对照组与观察组不良反应发生率〔8.7%(2/23)与13.0%(3/23)〕比较,差异无统计学意义(χ2=0.224,P>0.05)。结论细胞因子IL-2、IL-4、IFN-γ参与了华支睾吸虫感染引起的肝损伤的发生发展过程,黄芪注射液联合阿苯达唑对华支睾吸虫病患者的肝损伤具有保护作用,其机制可能与调节紊乱的细胞因子水平有关。Objective To observe the influence of albendazole combined with astragalus injection on the protection of liver injury and on the Th1 / Th2 cytokines in patients infected with clonorchis sinensis.Methods 46 patients infected with clonorchis sinensis were randomly divided into observation group and control group,with each group 23 cases,and meanwhile 23 healthy subjects were selected as normal control group.The control group was treated with albendazole,while the observation group was treated with albendazole combined with astragalus injection.The serum alanine aminotransferase(ALT),total bilirubin(TBIL),interleukin-2(IL-2),interleukin-4(IL-4) and interferon-gamma(IFN-γ) of the two groups were compared before and after treatment and compared with the normal control group,and the fecal eggs negative conversion rate and adverse effect of two groups was also observed.Results Before treatment,the ALT,TBIL,IL-2,IL-4 and IFN-γ levels in the three groups showed statistically significant differences(P < 0.05).The ALT,TBIL and IL-4 in control group and observation group were significantly higher than the normal control group,while the IL-2 and IFN-γ were significantly lower than the normal control group(P < 0.05).After treatment,the ALT and TBIL in the observation group were significantly lower than the control group,while the IL-2 and IFN-γ were significantly higher than the control group(P < 0.05).The negative conversion rate between the control group and observation group 〔91.3%(21 /23) vs.100.0%(23 /23) 〕showed no statistically significant difference(χ2= 2.091,P > 0.05).The incidence of adverse effect between the control group and observation group 〔8.7%(2/23) vs.13.0%(3/23) 〕showed no statistically significant difference(χ2= 0.224,P > 0.05).Conclusion The cytokine IL-2,IL-4,IFN-γ are involved in the development and progression of liver injury caused by clonorchis sinensis infection.The albendazole combined with astragalus injection have protective effect of liver injury caused by clonorchis sinensis inf

关 键 词：华支睾吸虫病 黄芪 阿苯达唑 TH1细胞 TH2细胞 

分 类 号：R532.23[医药卫生—内科学]