尿酸与糖尿病肾脏疾病代谢紊乱的关系分析  

ASSOCIATION OF ELEVATED URIL ALILL WITH METDBOLIT DISARDERS OF HYPTMRICERMILL IN TYPE 2 DIABETIC LEICLNEY DISEASE

作　　者：张丽英[1] 李永强[2] 

机构地区：[1]内蒙古医科大学附属医院肾内科,内蒙古呼和浩特010059 [2]南方医科大学第三附属医院肾内科

出　　处：《内蒙古医科大学学报》2013年第6期467-470,共4页Journal of Inner Mongolia Medical University

基　　金：国际肾脏病学会资助项目发展中国家KHDC项目先驱研究(2004-2014);广东省科技计划项目(2011B031800386)

摘　　要：目的:分析探讨住院病人2型糖尿病肾脏疾病(T2DKD)尿酸升高与代谢紊乱的关系及其危险因素。方法:收集105例糖尿病肾脏疾病(DKD)住院病人临床实验室资料,根据血尿酸浓度将105例DKD病人分为高尿酸组和正常尿酸组,分别检测两组血压、人体测量学指数、糖化血红蛋白、血脂、血尿酸、血肌酐及24h尿蛋白定量等指标,明确高尿酸血症(HUA)与DKD代谢紊乱的关系及其危险因素。结果:105例病人中HUA病人42例,占40.0%;单因素分析发现男性、体重指数(BMI)≥25 kg/m2、高血压、血肌酐(SCr)≥110μmol/L、血尿素氮(BUN)≥7.0 mmol/L、24h尿蛋白(24h-UAE)≥0.3g/24h、血甘油三酯(TG)≥1.70 mmol/L、血高密度脂蛋白(HDL)<1.04 mmol/L、血低密度脂蛋白(LDL)≥3.37 mmol/L等因素影响HUA的发生(P<0.05);Logistic回归分析提示BMI、SCr、TG水平是影响DKD发生HUA的独立危险因素;各主要危险因素在DKD中均有较高的发生率。结论:DKD尿酸升高与多种危险因素有关,HUA与DKD代谢紊乱密切关联。Objective:To investigate the association of elevated serum uric acid ( UA ) with metabolic disorders and the risk factors of 2 diabetic kidney disease(T2DKD). Methods:The clinical and laboratory data of 105 T2 DKD patients were analyzed to explore the association of hyperuricemia ( HUA) with metabolic disorders and identify the risk factors of HUA. Results:Forty of 105 DKD patients(40. 0%)were found to have HUA. Univariate analysis showed that male gender,a body mass index ≥25 kg/m2 ,hypertension,serum creatinine ≥110μmol/L,blood urea nitrogen ≥7. 0 mmol/L, 24h-UAE≥0. 3 g/24h, triglyceride ≥1. 70 mmol/L, high-density lipoprotein<1. 04 mmol/L, low density lipoprotein ≥3. 37 mmol/L were all risk factors of HUA ( P<0. 05 ) in DKD. Binary logistic regression analysis identified body mass index, serum creatinine and triglyceride as independent risk factors of HUA in DKD. The main risk factors related to HUA had high incidences in DKD.Conclusion:Several risk factors contribute to the occurrence of elevated serum uric acid in DKD,and metabolic disorders are also closely associated with HUA.

关 键 词：尿酸 糖尿病肾脏疾病 危险因素 

分 类 号：R589[医药卫生—内分泌]