调脂治疗对老年冠心病患者血管内皮功能的影响  

Effects of Blood Lipid Regulation Therapy on Vascular Endothelial Function in Elderly Patients with Coronary Heart Disease

作　　者：陈雯[1] 郭进[1] 郭文东[1] 

机构地区：[1]广西壮族自治区人民医院干部病房,广西南宁530021

出　　处：《广西中医学院学报》2004年第2期19-22,共4页Journal of Guangxi Traditional Chinese Medical University

摘　　要：[目的 ]探讨老年冠心病 (CHD)伴高脂血症患者在调脂治疗的同时对血管内皮功能的影响。 [方法 ]30例老年冠心病伴高脂血症患者 (A组 )服用血脂康调脂治疗前、后及 2 0例老年健康人对照组 (B组 )测定血总胆固醇 (TC)、甘油三脂(TG)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)、一氧化氮 (NO)、内皮素 (ET) ,采用高分辨超声检测肱动脉基础动脉内径(D0 )、内皮依赖性血流介导的舒张功能 (FMD)、非内皮依赖性硝酸甘油介导的舒张功能 (NID)。 [结果 ]A组治疗前的TC、TG、LDL、ET明显高于B组 (P <0 0 1 ) ,HDL、NO、FMD低于B组 (P <0 0 1 ) ,D0 、NID两组无显著性差异 (P >0 0 5 )。A组调脂治疗前、后比较 :治疗后TC、TG、LDL、ET降低 (P <0 0 5 ) ,HDL、NO、FMD升高 (P <0 0 5 ) ,D0 、NID无显著性改变。TC、TG、LDL与ET呈正相关 (P <0 0 1 ) ,与NO、FMD呈负相关 (P <0 0 1 ) ;HDL与FMD呈正相关 (P <0 0 1 )。 [结论 ]老年冠心病伴高脂血症患者存在血管内皮功能受损。血脂康在调脂治疗的同时 ,可显著降低ET ,提高NO、FMD 。Objective]To explore the effects of the blood lipid regulation therapy on vascular endothelial function in elderly coronary heat disease (CHD) patients with hyperlipidemia.[Methods] The study was carried out for two groups:Group A,the testing group with 30 cases of elderly CHD patients with hyperlipidemia and Group B,the control group with 20 cases of elderly healthy subjects. The patients in Group A were taking Xuezhikang to regulate the blood lipid. The blood biochemical indexes of the patients in Group A,i.e. fasting serum total cholesterol (TC),triglyceride (TG), high density lipoprotein cholesterol (HDL), low density lipoprotein cholesterol (LDL),plasma nitrogen oxide(NO),endothelin (ET) were tested before and after the blood lipid regulation therapy to compare with those of the patients in Group B,while the baseline inner diameter of brachial artery (D 0),the endothelium dependent blood flow mediated vasodilation (FMD) and non endothelium dependent nitroglycerin induced vasodilation (NID) were also measured by applying the high resolution ultrasound technique and compared with those of the patients in Group B as the per procedure mentioned above.[Results]Before therapy, TC,TG,LDL and ET values of the patients in Group A were significantly higher than those of the patients in Group B (P<0 01);in contrast, HDL,NO,FMD values of the patients in Group A were lower than those of the patients in Group B (P<0 01);D 0 and NID values,however, showed no obvious differences between the two groups (P>0 05).In Group A,the comparisons for the indexes before and after therapy were also carried out and indicated that after the therapy, TC,TG,LDL and ET lowered (P<0 05),HDL,NO,FMD increased (P<0 05),D 0 and NID showed no observable changes. TC,TG and LDL had the positive correlations with ET (P<0 01) and the negative correlations with NO and FMD (P<0 01).HDL had a positive correlation with FMD (P<0 01).[Conclusion]The vascular endothelial function dysfunction were occurring in the elderly CHD

关 键 词：冠心病 高脂血症 调脂治疗 血管内皮功能 

分 类 号：R541.4[医药卫生—心血管疾病]