新生儿缺氧缺血性脑病血清IL-18和TNF-α的水平及意义  

The levels of serum IL-18 and TNF-α in newborns with hypoxic-ischemic encephalopathy

作　　者：田发书 

机构地区：[1]河南宁陵县人民医院儿科,宁陵476700

出　　处：《中国实用神经疾病杂志》2013年第18期38-39,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨新生儿缺氧缺血性脑病(HIE)血清中白介素-18(IL-18)和肿瘤坏死因子-α(TNF-α)的水平及临床意义。方法采用双抗体夹心ELISA法检测37例HIE患儿和15例正常新生儿血清中IL-18、TNF-α的水平。结果 HIE患儿血清中IL-18、TNF-α水平急性期和恢复期均高于正常新生儿同期水平(P<0.05)。轻、中、重度HIE患儿急性期和恢复期血清中IL-18、TNF-α水平比较差异均有统计学意义(P<0.05)。不同程度HIE患儿的急性期和恢复期血清中IL-18、TNF-α水平比较差异有统计学意义(P<0.05)。结论 IL-18、TNF-α可能参与了HIE的病理生理学过程,两者水平检测可用于HIE的病情评估。Objective To investigate the levels of serum interleukin-18(IL-18)and tumor necrosis factor-α(TNF-α)in the newborns with hypoxic-ischemic encephalopathy(HIE)and their clinical significance.Methods The levels of serum IL-18 and TNF-αin the 37 cases of HIE and 15 cases of normal newborns were detected by double antibody sandwich ELISA assay.Results The levels of serum IL-18 and TNF-αin HIE were higher than these in normal newborns(P<0.05).The levels of serum IL-18 and TNF-αin acute HIE phase had a significant difference compared with these in HIE recovery phase.Conclusion IL-18 and TNF-αmay be involved in the pathophysiology process of HIE,which can be used to evaluate the degree of HIE.

关 键 词：新生儿 缺氧缺血性脑病 白介素-18 肿瘤坏死因子-Α 

分 类 号：R722.1[医药卫生—儿科]