冠状病毒非结构蛋白的研究进展  

RESEARCH ADVANCE ON NONSTRUCTRAL PROTEINS OF CORONAVIRUS

作　　者：边葶苈[1] 周继勇[1] 廖敏[1] 

机构地区：[1]浙江大学农业部动物病毒学重点实验室,杭州310058

出　　处：《中国动物传染病学报》2013年第4期67-74,共8页Chinese Journal of Animal Infectious Diseases

基　　金：教育部新世纪人才项目(NCET-09-0691);浙江省教育厅科研项目(Y201018247)

摘　　要：冠状病毒(Coronavirus)家族成员是许多家畜、宠物包括人类的重要病原,引起多种急性和慢性疾病。冠状病毒有一巨大的基因组RNA,全长27~32 kb,编码结构蛋白、非结构蛋白和一些辅助蛋白。冠状病毒非结构蛋白(nonstructural prtein,nsp)由病毒编码的多聚蛋白1a/1ab水解而来,共有15或16个。这些非结构蛋白参与调节病毒基因组RNA的复制和亚基因组RNA的转录,或作为转录/复制复合体参与基因组的复制转录,并参与感染宿主等过程,是冠状病毒重要的功能蛋白。随着冠状病毒引起的严重急性呼吸系统综合症(severe acute respiratory syndrome,SARS)在中国乃至全球的爆发,对冠状病毒尤其是其非结构蛋白的研究得到越来越多的重视。本文就冠状病毒非结构蛋白的研究进展做一综述。Coronaviruses are important pathogens and cause acute and chronic diseases in livestock animals, pets as well as human beings. All coronaviruses share a large RNA genome of 27-32 kb in length encoding structure proteins, nonstructural proteins (nsps) and some accessory proteins. There are a total of 15 or 16 nsps in coronaviruses, which are derived from genomic RNA-encoding polyprotein 1a/1ab by proteolytical cleavage with virus-encoded proteases. Nonstructural proteins are involved in the replication and transcription of genome RNA, formation of the replication/transcription complexes, or other processes of virus infection. Research on coronavirus nsps has received much attention since SARS outbreaks in 2002. This review briefly summarizes research advance on coronavirus nsps.

关 键 词：冠状病毒 非结构蛋白 研究进展 

分 类 号：S852.659.6[农业科学—基础兽医学]