冠心病患者血清亲环素A水平变化的临床意义  

Changes of cyclophilin A levels in patients with coronary heart disease

作　　者：袁伟[1] 严金川[1] 王丹青[1] 梁仪[1] 吴骏[1] 

机构地区：[1]江苏大学附属医院心内科,江苏镇江212001

出　　处：《江苏大学学报（医学版）》2013年第6期498-500,504,共4页Journal of Jiangsu University：Medicine Edition

基　　金：国家青年自然科学基金资助项目(81200222);镇江市社会发展支撑项目(SH2011053);镇江市心血管病学重点实验室基金资助项目(SS2012002)

摘　　要：目的:探讨不同危险分层的冠心病患者外周血亲环素A水平的变化及其与B型利钠肽(B-type natriuretic peptide,BNP)、肌钙蛋白I(troponin-I,TnI)水平和左心室射血分数(LVEF)的相关性。方法:选取冠心病患者84例,其中,稳定性心绞痛(SAP)组41例,急性冠脉综合征(ACS)组43例,后者包括不稳定型心绞痛(UAP)20例,急性心肌梗死(AMI)23例;同时选取无血管病变的患者43例作为非冠心病对照组。所有入组患者均在入院后即刻采血,AMI组入组患者均为发病12 h内,并在入院1周后再次采血。酶联免疫吸附试验(ELISA)测定血浆亲环素A的含量。结果:ACS组患者外周血亲环素A水平为(24.2±2.7)ng/mL,明显高于SAP组的(16.2±2.4)ng/mL和非冠心病对照组的(7.8±1.1)ng/mL(P均<0.05);AMI组和UAP组的外周血亲环素A水平分别为(24.1±2.4)ng/mL和(24.5±3.1)ng/mL,两组间比较差异无统计学意义;AMI组1周后亲环素A水平(17.9±3.0)ng/mL明显低于其急性期的(24.1±2.4)ng/mL(P<0.05)。ACS组BNP、TnI均明显高于对照组,而LVEF值低于对照组,冠心病患者外周血亲环素A水平的变化与BNP、TnI存在明显正相关(r=0.893,P<0.05;r=0.765,P<0.05),与LVEF存在明显负相关(r=-0.528,P<0.05)。结论:外周血亲环素A水平变化与冠心病患者的危险分层密切相关,可用于预测冠心病患者急性心脏事件的发生。Objective:To investigate the peripheral blood of cyclophilin A levels in the patient with coronary heart disease(CHD) and its correlation with BNP、TnI.Method:A total of 127 patients who underwent coronary angiography were selected as research subjects.They were divided into three groups by coronary angiography:41 cases of patients with stable angina as SAP;43 cases of patients with acute coronary syndrome as ACS,including two groups,20 cases of unstable angina as UAP,23 cases of myocardial infarction as AMI;43 cases of patients with non-coronary heart disease as control group.The blood of all patients were collected after in hospital,the AMI group was collected blood again after 1 week as recovery period.The cyclophilin A levels of all patients were measured with Elisa.Result:The cyclophilin A level in the ACS group was(24.2 ± 2.7) ng/mL,and was higher than that in the SAP group(16.2 ± 2.4) ng/mL and the control group(7.8 ± 1.1) ng/mL(P < 0.05),but there was no significant difference between the AMI group(24.1 ± 2.4) ng/mL and UAP group(24.5 ± 3.1) ng/mL.The cyclophilin A level in the AMI group(after 1 week) was lower than that in the acute stage [(17.9 ± 3.0) ng/mL vs(24.1 ± 2.4) ng/mL) ](P < 0.05).In the ACS group,the BNP,TnI levels were higher than the control group;the LVEF was lower than the control group.The cyclophilin A levels had positive correlation with BNP,TnI(r =0.893,P < 0.05;r = 0.765,P < 0.05),and had negative correlation with LVEF(r =-0.528,P < 0.05).Conclusion:The cyclophilin A levels had close relation to the stability of coronary heart disease,and maybe could predict the occurrence of thrombotic events in patients with CHD.

关 键 词：冠心病 亲环素A B型利钠肽 肌钙蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]