丹参多酚酸盐对首发脑梗死伴2型糖尿病患者肾功能的影响  

The impact of Salvianolate on renal functions in patients with first-ever ischemic stroke and type 2 diabetes mellitus

作　　者：余志良[1] 吴晓华[1] 李纬[1] 陆红梅[1] 韩瑛[1] 顾育明[1] 凌雪辉 

机构地区：[1]上海市第七人民医院脑病科,上海200137

出　　处：《神经病学与神经康复学杂志》2013年第3期147-150,共4页Journal of Neurology and Neurorehabilitation

基　　金：上海市浦东新区卫生局优秀学科带头人培养计划(编号:PWRd 2010-08)

摘　　要：目的：探讨丹参多酚酸盐注射剂对首发脑梗死伴2型糖尿病患者肾功能的影响。方法51例美国国立卫生研究院卒中量表（ NIHSS）评分居于6～20分之间的普通首发脑梗死伴2型糖尿病患者随机分为两组，治疗组26例，对照组25例，均给予常规治疗，治疗组加用丹参多酚酸盐注射剂200 mg/d，连用14 d。检测并对比两组患者治疗前后的尿素氮（ BUN）、肌酐（ Cr）、胱抑素C（Cys）和β微球蛋白（β-MG）指标的变化。结果两组治疗前肾功能无显著统计学差异（P均＞0.05），治疗后两组上述指标的差异则有统计学意义（ P均＜0.05）。结论丹参多酚对伴2型糖尿病的首发脑梗死患者的肾功能有一定保护作用。Objective To observe the impact of Salvianolate on renal functions in patients with first-ever ischemic stroke and type 2 diabetes mellitus . Methods Fifty-one diabetic patients with first-ever ischemic stroke ( NIHSS scores ranged from 6 to 20 ) were divided into the Salvianolate group ( n =26 ) and the control group (n=25).Both of them were given conventional treatment for 14 days, meanwhile the Salvianolate group was additionally treated with Salvianolate 200 mg/d intravenous injection .The renal function indexes , such as serum urea nitrogen ( BUN ) , serum creatinine ( Cr ) , cystatin C ( Cys ) , and β-microglobulin (β-MG ) were tested and compared before and after treatment . Results The renal functions had no statistically significant differences before treatment (all P>0.05), however, the results were the opposite after the treatment (all P<0.05). Conclusion The Salvianolate may have some protective impact on the renal function among patients with the first-ever ischemic stroke and type 2 diabetes mellitus .

关 键 词：丹参多酚酸 脑梗死 糖尿病 肾功能 

分 类 号：R285.6[医药卫生—中药学]