阿奇霉素序贯疗法治疗小儿支原体肺炎的疗效和安全性分析  

Efficacy and safety analysis of azithromycin sequential therapy on children with mycoplasma pneumonia

作　　者：王素霞[1] 王静[2] 任常军[3] 张晶[3] 韦翊[4] 

机构地区：[1]河北医科大学第一医院供应室,河北石家庄050031 [2]河北医科大学第一医院护理部,河北石家庄0500315 [3]河北医科大学第一医院儿科,河北石家庄050031 [4]杭州市第六人民医院儿科,浙江杭州310014

出　　处：《中国生化药物杂志》2014年第5期132-134,138,共3页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省医药卫生一般研究计划(2011KYB072)

摘　　要：目的探讨阿奇霉素序贯疗法在治疗小儿支原体肺炎中的临床效果和安全性。方法选取2011年12月~2012年12月河北医科大学第一医院儿科收治的106例支原体肺炎患儿,随机分为观察组和对照组。观察组(n=58)患儿在止咳、平喘、祛痰和退热等治疗的基础上予以阿奇霉素序贯疗法,对照组(n=58)患儿予以基础治疗联合红霉素治疗,观察比较2组患儿的症状改善情况,并评价2组的治疗效果。结果观察组患儿咳嗽消失时间、发热消失时间和肺啰音消失时间均显著低于对照组,差异有统计学意义(P<0.05);对照组治疗后总有效率为74.1%,观察组为98.3%,2组比较差异有统计学意义(P<0.05);对照组住院时间为(11.2±2.2)d,不良反应发生率为41.4%,观察组的住院时间为(8.4±1.6)d,不良反应发生率为13.8%,2组比较差异有统计学意义(P<0.05)。结论阿奇霉素序贯疗法可快速缓解支原体肺炎患儿的症状,缩短住院时间,且不良反应相对较少。Objective To investigate the efficacy and safety analysis of azithromycin sequential therapy on children with mycoplasma pneumonia. Methods 56 children with mycoplasma pneumonia chosed from the First Hospital of Hebei Medical University From December 2011 to December 2012,were randomly divided into treatment and control groups. 58 cases in treatment group were treated with azithromycin sequential therapy on the basis of antitussive,anti-asthmatic,expectorant and anti-febrile treatment,58 cases in control group were treated with erythromycin injection therapy under the basic treatment. The improvement symptoms and the therapeutic effects in both group were compared and evaluated. Results Cough disappearance time,fever disappearance time and pulmonary rales disappearance time of treatment group were significantly shorter than control group,and the difference between two groups were statistically significance(P < 0. 05). The total effective of treatment group was 98. 3%,and 74. 1% in control groups,and the difference between two groups was statistically significance( P < 0. 05). The length of stay was(8. 4 ± 1. 6) d and the occurrence of adverse reactions was 13. 8% in treatment group,which was(11. 2 ± 2. 2)d and 41. 4% in control group,there were significant differences between two groups( P < 0. 05). Conclusion Azithromycin sequential therapy in treatment of mycoplasma pneumonia can rapidly alleviate the clinical symptoms. Azithromycin not only makes the length of stay shorter,but also has less adverse reactions.

关 键 词：阿奇霉素 序贯疗法 小儿 支原体肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]