2型糖尿病患者振动觉阈值检测及影响因素  

Vibration perception threshold of type 2 diabetic patients and its influencing factors

作　　者：沈娟[1] 刘芳[1] 曾辉[1] 赵俊功[2] 赵珺[3] 董杨[4] 贾伟平 

机构地区：[1]上海市糖尿病临床医学中心,上海市糖尿病研究所,上海市糖尿病重点实验室,上海交通大学第六人民医院内分泌代谢科,200233 [2]上海交通大学第六人民医院放射介入科,200233 [3]上海交通大学第六人民医院血管外科,200233 [4]上海交通大学第六人民医院骨科,200233

出　　处：《中华糖尿病杂志》2009年第6期-,共4页CHINESE JOURNAL OF DIABETES MELLITUS

摘　　要：目的 探讨振动觉阈值检测对2型糖尿病患者下肢神经病变的诊断意义及其影响因素.方法 测定2008年8月至2009年4月在我院内分泌代谢科门诊就诊的1018例2型糖尿病患者振动觉阈值,根据振动觉阈值风险度将其分为低风险组(<15 V)484例、中风险组(15～25 V)302例、高风险组(>25 V)232例.比较患者下肢神经病变症状、基本情况和血糖控制指标,分析其影响因素.采用卡方检验、t检验、单因素方差分析等进行统计学分析.结果 低风险组、中风险组、高风险组分别占47.54%、29.67%、22.79%,中风险组、高风险组有神经病变症状者所占比例明显高于低风险组(分别为61.26%、65.52%、39.26%).各组年龄、糖尿病病程、收缩压、糖化血红蛋白及糖化血清蛋白差异有统计学意义(均P<0.05),男性振动觉阈值明显高于女性(P<0.01).振动觉阈值与年龄、性别、糖尿病病程、收缩压、糖化血红蛋白、糖化血清蛋白、空腹血糖呈正相关(P<0.05).多元回归分析显示年龄(P=0.000)、糖化血红蛋白(P=0.046)及糖化血清蛋白(P=0.030)是振动觉阈值的独立影响因素.结论 采用振动觉阈值检测筛查门诊2型糖尿病患者糖尿病周围神经病变的患病率为22.79%,年龄、糖化血红蛋白、糖化血清蛋白是振动觉阈值的独立影响因素.Objective To investigate the morbidity rate of diabetic peripheral neuropathy (DPN) and analyze its related factors through the testing of the vibration perception threshold (VPT) in outpatients with type 2 diabetes meUitus (T2DM). Methods VPT on both feet in 1018 T2DM outpatients was examined by the quantitative examination equipment of vibration perception. The participants were then assigned to the low-risk group (<15 V, n=484), mediate-risk group (15 to 25 V, n=302), and high-risk group (> 25 V, n=232). The clinical characteristics and biochemical parameters were compared. Results The patients in the low-risk, mediate-risk, and high-risk group accounted for 47.54%, 29.67%, and 22.79%, respectively. The patients with neuropathy symptoms accounted for 39.26%, 61.26%, and 65.52% in the low-risk, mediate-risk, and high-risk group, respectively. There were significant differences in age, diabetic duration, systolic blood pressure (SBP), glycated hemoglobin (HbA1c) and glycated serum albumin (GA) among the three groups (all P < 0.05). VPF of male patients was worse than that of female patients (P < 0.01). VPT was positively correlated with age, gender, diabetic duration, SBP, HbA1c, GA, and fasting plasma glucose (FPG) (all P <0.05). In multiple stepwise regression analysis, age (P=0.000), HbA1c (P=0.046), and GA (P=0.030) were independent influencing factors of VPT. Conclusions The prevalence of DPN was 22.79% screened by VFF examination in type 2 diabetic outpatients. Age, HbA1c and GA may be independent influencing factors of VPT.

关 键 词：糖尿病周围神经病变 振动觉阈值 影响因素 

分 类 号：R587[医药卫生—内分泌]