家兔须癣毛癣菌对8种抗真菌药物敏感性研究  

Study on Susceptibility of Eight Kind of Antifungal Medicines to Trichophyton Mentagrophytes 0f Rabbit

作　　者：林毅[1] 谢晶[1] 李兴玉[1] 魏甬[1] 王文贵[1] 张先惠[1] 于吉锋[1] 罗丹丹[1] 

机构地区：[1]四川省畜牧科学研究院,成都610066

出　　处：《中国养兔》2011年第4期15-18,共4页Chinese Journal of Rabbit Farming

摘　　要：采用丹麦ROSCO药敏纸片扩散法,检测12株家兔须癣毛癣菌对伊曲康唑、酮康唑、氟康唑、特比萘酚、克霉唑、氟胞嘧啶、沃尔康唑和制霉菌素等8种抗真菌药物的敏感性。结果:特比萘酚对须癣毛癣菌的抑菌圈直径最大(平均73 mm),而且12株菌100%对其敏感,抗菌效果最好;其后依次是沃尔康唑、克霉唑和伊曲康唑,按ROSCO严格判读标准12株菌对其敏感率分别为83.3%、83.3%和8.3%;抑菌效果最差的是氟胞嘧啶和氟康唑,按ROSCO基本判读标准其耐药(不敏感)率分别为100%和83.3%。The susceptibility of 12 isolates of Trichophyton mentagrophytes from rabbit were tested to Itraconazole,Ketoconazole,Fluconazole,Terbinafine,Clotrimazole,5-Fluorocytosine,Vorconazole and Nystatin by Denmark Rosco disk diffusion method.The inhibitory ring diameter of Terbinafine were the biggest(average 73 mm),moreover,the sensitive rate of Terbinafine to 12 isolates were 100% and its antifungal effect was the best.According to the more stringent criteria of ROSCO,the sensitive rates of Vorconazole,Clotrimazole and Itraconazole to 12 isolates were 83.3%,83.3% and 8.3%,respectively.The antifungal effect of 5Fluorocytosine and Fluconazole were the worst,which resistance(insensitive) rate were respectively 100% and 83.3% according to basic criteria of ROSCO.

关 键 词：兔 须癣毛癣菌 抗真菌药物 ROSCO药敏纸片扩散法 

分 类 号：S858.291[农业科学—临床兽医学]