茴拉西坦有关物质测定方法的改进  

Improved HPLC Method for Determination of Related Substances in Aniracetam

作　　者：郭志渊 傅萍[1] 谢华[1] 张悦杨[1] 

机构地区：[1]四川省食品药品检验所,成都610097

出　　处：《中国现代应用药学》2013年第1期84-86,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的改进茴拉西坦的有关物质测定方法。方法采用高效液相色谱法,以C18为色谱柱,流动相为乙腈-水(35∶65),检测波长为254nm。结果茴拉西坦与其降解产物在该色谱条件下能够有效分离。结论该方法准确可靠,可用于测定茴拉西坦的有关物质测定。OBJECTIVE To improve an HPLC method for determination of the related substances in aniracetam.METHODS The column was C18 colum.Mobile phase was acetonitrile-water(35∶65).The detection wavelength was 254 nm.RESULTS Aniracetam and its related substances can be separated effectively by this method.CONCLUSION The method is accurate and reliable.It can be used for the related substances determination in aniracetam.

关 键 词：高效液相色谱法 茴拉西坦 有关物质 

分 类 号：R927[医药卫生—药学]