Exploitation of host clock gene machinery by hepatitis viruses B and C  

作　　者：Manlio Vinciguerra Gianluigi Mazzoccoli Claudia Piccoli Tiziana Tataranni Angelo Andriulli Valerio Pazienza 

机构地区：[1]Institute for Liver and Digestive Health,Division of Medicine,University College London (UCL),London SW7 2AZ,United Kingdom [2]Gastroenterology Unit,IRCCS "Casa Sollievo della Sofferenza" Hospital,71013 San Giovanni Rotondo (FG),Italy [3]Department of Medical Sciences,Division of Internal Medicine,IRCCS Scientific Institute and Regional General Hospital "Casa Sollievo della Sofferenza",71013 San Giovanni Rotondo (FG),Italy [4]Department of Clinical and Experimental Medicine,University of Foggia,71100 Foggia,Italy [5]Laboratory of Pre-Clinical and Translational Research,IRCCS,Centro di Riferimento Oncologico della Basilicata (CROB),85028 Rionero in Vulture (PZ),Italy

出　　处：《World Journal of Gastroenterology》2013年第47期8902-8909,共8页世界胃肠病学杂志（英文版）

基　　金：Supported by RC1303GA49 and Italian Ministry of Health(Pazienza V);MV and VP are supported by Bando GR-2010-2311017 and by the"5x1000"voluntary contributions to IRCCS"Casa Sollievo della Sofferenza"Hospital(Vinciguerra M and Pazienza V);and the Associazione Italiana per la Ricerca sul Cancro(AIRC)program MyFAG(Vinciguerra M)

摘　　要：Many aspects of cellular physiology display circadian(approximately 24-h)rhythms.Dysfunction of the circadian clock molecular circuitry is associated with human health derangements,including neurodegeneration,increased risk of cancer,cardiovascular diseases and the metabolic syndrome.Viruses triggering hepatitis depend tightly on the host cell synthesis machinery for their own replication,survival and spreading.Recent evidences support a link between the circadian clock circuitry and viruses’biological cycle within host cells.Currently,in vitro models for chronobiological studies of cells infected with viruses need to be implemented.The establishment of such in vitro models would be helpful to better understand the link between the clock gene machinery and viral replication/viral persistence in order to develop specifically targeted therapeutic regimens.Here we review the recent literature dealing with the interplay between hepatitis B and C viruses and clock genes.Many aspects of cellular physiology display circadian (approximately 24-h) rhythms. Dysfunction of the circadian clock molecular circuitry is associated with human health derangements, including neurodegeneration, increased risk of cancer, cardiovascular diseases and the metabolic syndrome. Viruses triggering hepatitis depend tightly on the host cell synthesis machinery for their own replication, survival and spreading. Recent evidences support a link between the circadian clock circuitry and viruses’ biological cycle within host cells. Currently, in vitro models for chronobiological studies of cells infected with viruses need to be implemented. The establishment of such in vitro models would be helpful to better understand the link between the clock gene machinery and viral replication/viral persistence in order to develop specifically targeted therapeutic regimens. Here we review the recent literature dealing with the interplay between hepatitis B and C viruses and clock genes.

关 键 词：HEPATITIS C VIRUS HEPATITIS B VIRUS ANTIHEPATITIS therapy Clock genes CHRONOBIOLOGY 

分 类 号：R512.6[医药卫生—内科学]