Atheromatous plaque rupture may due to fatigue crack growth under cyclic blood pressure:A comparison between symptomatic and asymptomatic individuals  

作　　者：Xuan Pei Zhiyong Li 

机构地区：[1]School of Biological Science and Medical Engineering,Southeast University

出　　处：《医用生物力学》2013年第S1期43-46,共4页Journal of Medical Biomechanics

基　　金：partially supported by the National 973 Basic Research Program of China (No.2013CB733803);the National Natural Science Foundation of China(NSFC)(No.11272091)

摘　　要：Introduction Stroke or heart attack,the leading cause of death and disability worldwide,is usually caused by rupture of atheromatous plaque.Therefore,the identification of vulnerable atheroma pre rupture has become extremely important for patient risk stratification.Previous studies have shown that the vulnerable plaque,i.e.one that is prone to rupture with thromboembolic complications,is often associated with a thin fibrous cap,a large lipid core and a high inflammatory burden.The mechanism of plaque rupture is not entirely clear but is thought to be a multi-factorial process involving thinning and weakening of the fibrous cap by enzymes secreted by activa-Introduction Stroke or heart attack,the leading cause of death and disability worldwide,is usually caused by rupture of atheromatous plaque.Therefore,the identification of vulnerable atheroma pre rupture has become extremely important for patient risk stratification.Previous studies have shown that the vulnerable plaque,i.e.one that is prone to rupture with thromboembolic complications,is often associated with a thin fibrous cap,a large lipid core and a high inflammatory burden.The mechanism of plaque rupture is not entirely clear but is thought to be a multi-factorial process involving thinning and weakening of the fibrous cap by enzymes secreted by activa-

关 键 词：plaque rupture fibrous VULNERABLE DISABILITY ASYMPTOMATIC extremely stratification WEAKENING THINNING 

分 类 号：R541.4[医药卫生—心血管疾病]