How does stiffness of trabecular meshwork affect outflow resistance in human eyes?  

作　　者：Fan Yuan Lucinda J.Camras W.Daniel Stamer David Epstein Pedro Gonzalez 

机构地区：[1]Department of Biomedical Engineering,Duke University [2]Department of Ophthalmology,Duke University

出　　处：《医用生物力学》2013年第S1期86-88,共3页Journal of Medical Biomechanics

摘　　要：Purpose Ocular hypertension is the primary risk factor for development of glaucoma and the only modifiable endpoint^[1,2].Clinical trials involving thousands of patients have shown consistently that lowering intraocular pressure（IOP）in those with glaucoma,whether or not their IOP is above normal,slows vision loss.IOP elevation is the result of diminished outflow facility in the conventional outflow pathway;and the highest resistance to aqueous humor outflow resides in the juxtacanalicular tissue（JCT）layer of trabecular meshwork（TM）and the inner wall of Schlemm’s canal（SC）.However,mechanisms of outflow facility decrease in glaucomatous eyes remain to be determined.Purpose Ocular hypertension is the primary risk factor for development of glaucoma and the only modifiable endpoint[1,2].Clinical trials involving thousands of patients have shown consistently that lowering intraocular pressure（IOP）in those with glaucoma,whether or not their IOP is above normal,slows vision loss.IOP elevation is the result of diminished outflow facility in the conventional outflow pathway;and the highest resistance to aqueous humor outflow resides in the juxtacanalicular tissue（JCT）layer of trabecular meshwork（TM）and the inner wall of Schlemm’s canal（SC）.However,mechanisms of outflow facility decrease in glaucomatous eyes remain to be determined.

关 键 词：OUTFLOW TRABECULAR glaucoma INTRAOCULAR facility consistently STIFFNESS CANAL lowering ENDPOINT 

分 类 号：R312[医药卫生—基础医学]