手法治疗对椎动脉型颈椎病患者血浆内皮素的影响  

Effects of Endothelin-1 in Vertebral Artery Type of Cervical Spondylosis by Manipulation Therapy and Jinzhuyalong Ershiwuwei Coral Capsule

作　　者：王争羊[1] 段虹[1] 罗晓阳[1] 马晓菊[1] 李卫华[1] 黄运菊[1] 白博[1] 田瑞琴[1] 

机构地区：[1]空军临潼航空医学鉴定训练中心,西安710600

出　　处：《中国实用内科杂志》2013年第S2期9-11,共3页Chinese Journal of Practical Internal Medicine

摘　　要：目的探讨手法治疗椎动脉型颈椎病的临床疗效和内皮素-1(ET-1)变化及作用。方法通过放射免疫测定法(RIA)测定椎动脉型颈椎病患者进行手法及二十五味珊瑚胶囊治疗前后血浆ET-1含量。结果椎动脉型颈椎病患者组血浆ET-1明显高于正常对照组(P<0.05),椎动脉型颈椎病患者手法治疗ET-1明显低于手法治疗前(P<0.05),手法配合二十五味珊瑚胶囊治疗ET-1明显低于手法治疗组、服药组(P<0.05)。结论ET-1增高是造成椎动脉型颈椎病持续缺血的重要因素。血浆ET-1降低的幅度,手法组与服药组接近,故手法治疗可代替药物治疗通过降低血浆ET-1改善椎动脉持续缺血从而减轻临床症状。Objective To study the changes and effects of plasme Endothelin-1 in vertebral artery type of cervical spondylosis patients by manipulation therapy and Jinzhuyalong Ershiwuwei Coral Capsule.Methods Before and after manipulation therapy and Jinzhuyalong Ershiwuwei Coral Capsule,the levels of Endothelin-1 in the plasma of vertebral artery type of cervical spondylosis group and normal contrast group were detected by radioimmunoassay(RIA).Results The levels of Endothelin-1 in the plasma was significantly increased in vertebral artery type of cervical spondylosis group compared with those in the control group(P < 0.05).After the manipulation therapy or Jinzhuyalong Ershiwuwei Coral Capsule therapy,the levels of plasma Endothelin-1 in vertebral artery type of cervical spondylosis group was notably increased(P < 0.05).Conclusion The increase of Endothelin-1 in the plasma is a important factor which causes continue ischemia of vertebral artery in cervical spondylosis.The manipulation therapy and Jinzhuyalong Ershiwuwei Coral Capsule therapy therapy can improve blood-suppy of vertebral artery by decreaseing the levels of Endothelin-1 in plasma.

关 键 词：椎动脉型颈椎病 手法治疗 药物 内皮素-1 

分 类 号：R681.55[医药卫生—骨科学]