Synthesis of Mesoporous Silica Nanoparticles with Tunable Shape and Size  

作　　者：仇可新 何创龙 冯炜 王伟忠 周小军 尹郅祺 陈良 莫秀梅 

机构地区：[1]State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,Donghua University [2]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University [3]College of Materials Science and Engineering,Donghua University

出　　处：《Journal of Donghua University(English Edition)》2013年第5期435-438,共4页东华大学学报（英文版）

基　　金：National Natural Science Foundation of China(No.31271028);Shanghai Natural Science Foundation,China(No.11ZR1400100);Shanghai Nano Science Program,China(No.11nm0505500);Innovation Program of Shanghai Municipal Education Commission,China(No.13ZZ051);Fundamental Research Funds for the Central Universities,China;Open Foundation of State Key Laboratory for Modification of Chemical Fibers and Polymer Materials,China(No.LK1202);Chinese Universities Scientific Fund(No.13D310608);the Scientific Research Foundation for Returned Scholars,Ministry of Education of China

摘　　要：The structural and morphological properties of mesoporous silica nanoparticles( MSNs) have dramatical influence on their in vivo biological behaviors,and thereby synthesis of MSNs with well-defined shape and size has recently attracted much more attention in the biomedical field. The synthesis of MSNs with controllable size and shape was presented by controlling the reaction temperature and the concentration of templating agent(cetyltrimethylammonium bromide,CTAB). The results indicated that MSNs were larger in particle size and more round in shape with increasing of the reaction temperature,but their particle size and dispersivity became smaller and poorer as CTAB concentration increased. Therefore,the particle size and shape of MSNs can be tuned by using the optimal synthesis conditions for specific biomedical applications.The structural and morphological properties of mesoporous silica nanoparticles( MSNs) have dramatical influence on their in vivo biological behaviors,and thereby synthesis of MSNs with well-defined shape and size has recently attracted much more attention in the biomedical field. The synthesis of MSNs with controllable size and shape was presented by controlling the reaction temperature and the concentration of templating agent(cetyltrimethylammonium bromide,CTAB). The results indicated that MSNs were larger in particle size and more round in shape with increasing of the reaction temperature,but their particle size and dispersivity became smaller and poorer as CTAB concentration increased. Therefore,the particle size and shape of MSNs can be tuned by using the optimal synthesis conditions for specific biomedical applications.

关 键 词：MESOPOROUS SILICA nanoparticles surfactant-templating method particle SIZE DISPERSIVITY 

分 类 号：TB383.1[一般工业技术—材料科学与工程]