自噬与能量代谢  

Autophagy and energy metabolism

作　　者：邓玉杰[1] 杨颖[1] 

机构地区：[1]200025 上海市内分泌代谢病研究所,上海市内分泌代谢病临床医学中心,上海交通大学医学院附属瑞金医院内分泌代谢病科

出　　处：《中华内分泌代谢杂志》2014年第4期-,共4页Chinese Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目

摘　　要：真核细胞通过调节细胞内蛋白质的降解和细胞器的更新来维持内稳态.自噬是一种类泛素化的降解过程,在维持细胞生存、分化和胞内物质清理方面发挥重要作用.之前关于自噬的研究主要集中在肿瘤、神经变性疾病等方面,自噬与能量代谢的研究很少.2009年开始陆续有关于自噬调节代谢方面的研究,本文综述了最新的关于自噬与脂肪细胞分化、自噬与脂滴的储存与分解的研究进展.Eukaryotic cells maintain cellular homeostasis by regulating the process of protein degradation and organelle turnover.Autophagy is a ubiquitin-like degradation process,and plays an essential role in cellular development,differentiation,and elimination of damaged organelles and protein.Previous studies mostly focused autophagy on tumor and neurodegenerative diseases,whereas studies about autophagy and energy remain not clear.Since 2009,an increasing number of studies have showed light on the importance of autophagy in regulating lipid metabolism.The review focuses on the relationship between autophagy and differentiation of adipocytes,lipogenesis,and lipolysis.

关 键 词：自噬 能量代谢 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]