功能显像在糖尿病诊断中的应用与展望  

Application of functional imaging in diagnosis of diabetes mellitus

作　　者：黄喆慜[1] 张政伟[1] 左传涛[1] 管一晖[1] 

机构地区：[1]复旦大学附属华山医院PET中心,上海,200235

出　　处：《中华内分泌代谢杂志》2014年第4期-,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：不论是1型还是2型糖尿病,其中都有显著的β细胞量的损失,了解β细胞量在糖尿病病程中的变化对于糖尿病的诊断及治疗将提供重要的信息.以核磁共振显像、正电子发射断层显像(PET)等为代表的功能显像方法因其具有实用性、非创伤性以及安全性等特点,在β细胞量检测中存在潜在的应用价值.其中,放射性核素标记的影像技术是针对人体β细胞最敏感的显像方法,在针对β细胞量的dihydrotetrabenazine PET显像上,已取得了初步研究结果.对于导致2型糖尿病的关键因素,18F-6-葡萄糖(18F-6-deoxy-6-fluoro-D-glucose,18F-6-FDG)已被证明是活体研究葡萄糖转运状态的有效示踪剂,因而其在反应胰岛素抵抗状态中具有潜在研究价值.进一步发展糖尿病的功能影像学诊断研究对于明确糖尿病的发病机制、建立客观的早期诊断方法以及评估各类治疗方法的有效性具有潜在巨大的应用价值.In either type 1 or type 2 diabetes,there is significant loss of β cell mass.Understanding the changing of β cell mass in the course of diabetes would provide important information for diagnosis and treatment.Functional imaging like magnetic resonance imaging or positron emission tomography (PET) can provide safe and noninvasive detection of loss of β cell mass in the course of diabetes.Among them,radio-labelled imaging is the most sensitive imaging procedure of the β cell ; For dihydrotetrabenazine PET imaging aiming β cell mass,there has been some primary outcome.For the key factor causing type 2 diabetes,18 F-6-deoxy-6-fluoro-D-glucose (18F-6-FDG) PET imaging is an effective tracer to study the glucose transporting condition in vivo.Further development of functional imaging will be of great value in diagnosis and treatment of diabetes.

关 键 词：糖尿病 功能显像 β细胞量 葡萄糖转运体 

分 类 号：R587.1[医药卫生—内分泌]