β3肾上腺素能受体基因多态与新疆哈萨克族人腹型肥胖和代谢综合征的相关研究  

Association of morbid obesity,metabolic syndrome and polymorphism of β3-adrenergic receptor gene in the Hasake population in xinjiang

作　　者：郭艳英[1] 潘慧娟 王坤[3] 赵蕾[3] 何秉贤[3] 

机构地区：[1]新疆维吾尔自治区人民医院干一科,新疆,乌鲁木齐,830001 [2]广东省深圳市南山区西丽人民医院内科 [3]新疆医科大学第一附属医院心血管中心

出　　处：《中国医师杂志》2008年第8期-,共3页Journal of Chinese Physician

摘　　要：目的 检测新疆哈萨克族人群中β3肾上腺素能受体(β3-AR)Trp64Arg位点的等位基因频率和基因型频率,分析β3-AR基因在腹型肥胖、代谢综合征发生、发展中的作用.方法 应用聚合酶链反应和限制性片断长度多态性技术检测172例代谢综合征(MS)、92例单纯腹型肥胖和92例正常人的基因型,同时测定相关的生化指标,进行病例-对照研究.结果 β3-AR Trp64Arg位点的基因型频率在三组间差异无统计学意义.结论 β3-AR Trp64Arg多态与哈萨克族人腹型肥胖、MS的发生无明显关联.Objective To investigate the genotype of Trp64Arg polymorphism of β3-adrenergic receptor gene and analyze the role ofβ3-adrenerglc receptor gene in the pathogenesis of morbid obesity and metabolic syndrome(MS).Methods PCR-restriction fragment length polymorphism Was used to detect the genotypes of 172 patients with MS,92 patient.with morbid obesity and 92 controls,and some biochemlcal indexes were detected.The association of the polymorohism with morbid obesity and MS Was assessed in case-control study.Resuits No statistically significant differences were found in the frequencies of Trp64Arg of β3-AR among the three groups.Conclusion Trp64Arg polymorphism of β3-AR was not significandy associated with morbid obesity and MS in the Hazak in xinjiang.

关 键 词：受体 肾上腺素能β3 多态现象 遗传 肥胖症 代谢综合征X 

分 类 号：R589[医药卫生—内分泌]