狂犬病灭活疫苗CVS-11株对牛的免疫效果  

Evaluation of immune efficacy of the inactivated rabies vaccine CVS-11 strain in adult cattle

作　　者：刘晔[1] 张菲[1] 张守峰[1] 连海[1] 李楠[1] 乌仁格格 扈荣良[1] 

机构地区：[1]中国人民解放军军事医学科学院军事兽医研究所吉林省人兽共患病预防与控制重点实验室,吉林长春130122 [2]河套学院理学系,内蒙古巴彦淖尔015000

出　　处：《中国兽医学报》2015年第6期938-940,共3页Chinese Journal of Veterinary Science

基　　金：国家863计划资助项目(2011AA10A212)

摘　　要：野生狐和貉狂犬病流行于新疆、内蒙古和黑龙江地区,是当地牛、羊和骆驼等家畜狂犬病的主要传染源。在国内尚无野生动物口服疫苗的前提下,对家畜进行狂犬病灭活疫苗接种,具有重要的公共卫生学意义。本研究利用国产犬用狂犬病灭活疫苗(CVS-11株)对牛进行了免疫效果和安全性评价。以不同剂量疫苗肌内注射免疫成年牛350头,通过比较免疫后狂犬病病毒中和抗体水平和持续期,确定犬用狂犬病灭活疫苗(CVS-11株)在牛的最佳免疫剂量为1次性注射2剂量疫苗,免疫持续期为1年。结果表明,犬用狂犬病灭活疫苗(CVS-11株)免疫牛时,具有较高的免疫原性和安全性,适用于牛等大型动物的狂犬病注射免疫。Rabies in wild foxes and raccoon dogs occur in Heilongjiang province,Xinjiang and Inner Mongolia autonomous region.Because of no oral vaccine for wildlife animals,domestic animals in these region should been immunized with inactivated rabies vaccine.To evaluate the biosafety and the immunogenic effectiveness of the inactivated rabies vaccine(CVS-11strain),350 adult cattle were muscularly injected with different doses of CVS-11 strain.Results showed that 2-dose vaccination should be administered once for rabies pre-exposure prophylaxis in cattle.The results demonstrated that the inactivated rabies vaccine(CVS-11strain)is not only safe,but also effective in cattle,which provided important data for the application of the vaccine in large animals.

关 键 词：狂犬病 疫苗 免疫 牛 评价 

分 类 号：S859.79[农业科学—临床兽医学]