围产期健康奶牛血清和初乳中免疫球蛋白含量的变化  

Changes of immunoglobulin protein content in serum and colostrum during healthy periparturient dairy cows

作　　者：李刚诗[1] 王晓艳[2] 袁听[2] 周紫峣[1] 唐天亮[1] 石先鹏[1] 谷武阳[1] 解冰冰[1] 王方园[1] 李魏[1] 刘长松[1] 彭广能[1] 钟志军[1] 

机构地区：[1]四川农业大学动物医学院动物疫病与人类健康四川省重点实验室,四川雅安625014 [2]重庆三峡职业学院动物科技系,重庆万州404100

出　　处：《中国兽医学报》2015年第2期273-277,共5页Chinese Journal of Veterinary Science

基　　金：四川省科技厅科技支撑计划资助项目(2011NZ0060);国家自然科学基金资助项目(31272620);教育部"长江学者与创新团队发展规划"创新团队资助项目(IRT0848);四川农业大学双支计划资助项目(03570316;03570362)

摘　　要：为探讨围产期奶牛血清和初乳中免疫球蛋白含量的变化,采用免疫抑制法测定血清和初乳中Ig G、Ig A、Ig M的含量,并分析其与产奶量之间的关系。结果显示,奶牛围产期血清中Ig G、Ig A、Ig M含量均先降低后升高,与分娩当天相比,产前21 d时三者含量分别减少62.1%,65.2%,62.6%,而产后21 d时其含量仍未恢复到产前21 d时的水平;初乳中Ig G、Ig A、Ig M含量随泌乳时间的延长逐渐降低。此外,产前血清中免疫球蛋白含量的减少量和初乳中免疫球蛋白含量与产奶量呈负相关性。试验表明,奶牛在围产期阶段处于免疫抑制状态,表现为产前免疫球蛋白的减少和分娩前后低水平的免疫球蛋白水平,这些变化可能是导致围产期奶牛较高发病率的原因之一。To explore the immune status in periparturient period of dairy cows,the concentrations of Ig G,Ig A and Ig M in serum and colostrum were investigated by immunoglobulin assay kit,and assessed whether the variation in immunoglobulin levels is related to milk productions. The results showed that the concentrations of Ig G,Ig A and Ig M were significantly decreased at first and increased in serum during the periparturient period. Compared with the 0 d group,the reduced rate of Ig G,Ig A and Ig M were 62. 1%,65. 2%and 62. 6% at- 21 d group. Concentrations of Ig G,Ig A and Ig M were negative correlation with the time,respectively. In addition,the contents of prenatal serum and colostrum immunoglobulin were both negatively correlated with the milk yield. This study showed that the immune state in the perinatal stage of dairy cows had been suppressed,such as the low levels of prenatal immunoglobulins,which may cause the higher incidence of infective diseases in this period of cows.

关 键 词：围产期健康奶牛 免疫球蛋白G 免疫球蛋白A 免疫球蛋白M 产奶量 

分 类 号：S823[农业科学—畜牧学]