速度向量成像技术评价急性心肌缺血左心室扭转运动  

Left Ventricular Twist in Rabbit with Acute Myocardial Ischemia Assessed by Velocity Vector Imaging

作　　者：周佳[1,2] 蒲大容[1] 周启昌[1] 曾施[1] 田蕾琪[1] 刘红雨[2] 童海[2] 

机构地区：[1]中南大学湘雅二医院超声科,湖南省长沙市410011 [2]南华大学附属第一医院超声科,湖南省衡阳市421001

出　　处：《中国动脉硬化杂志》2015年第1期29-32,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金资助(30970838)

摘　　要：目的建立新西兰大白兔急性心肌缺血动物模型,应用速度向量成像(VVI)技术分析急性心肌缺血状态下左心室扭转运动的变化特点。方法新西兰大白兔40只,随机分为急性心肌缺血组和假手术组,于冠状动脉结扎术前和术后30 min内行超声心动图检查并采集动态图像,脱机行VVI分析,测量左心室心尖水平及心底水平的旋转角度峰值、旋转速度峰值、解旋速度峰值。结果急性心肌缺血组术后,心底水平左心室旋转角度、旋转速度及解旋速度有减低趋势,但与术前及假手术组比较差异无统计学意义(P>0.05);心尖水平左心室旋转角度、旋转速度及解旋速度均明显减低,与术前及假手术组比较差异均有统计学意义(P<0.05),左心室整体扭转角度、速度和解旋速度术后改变趋势与心尖水平相似,与术前及假手术组比较差异均有统计学意义(P<0.05)。结论急性心肌缺血后,左心室扭转和解旋功能受损,主要由心尖部旋转和解旋减低引起。VVI技术能够客观、准确地检测实验兔左心室扭转的变化特征,为急性心肌缺血的早期诊断提供了一种新的、无创的、可靠的定量工具。Aim To use velocity vector imaging( VVI) to monitor changes in left ventricular twist in a New Zealand white rabbit model of acute myocardial ischemia. Methods Forty rabbits were randomly assigned to acute myocardial ischemia group and sham operation group. All rabbits were examined by dynamic echocardiography before the ligation or sham operation and again within 30 minutes afterwards. Peak rotate angle,peak twist velocity and peak untwist velocity were measured by VVI in the basal and apical level of the left ventricular myocardium. Results Peak rotate angle,peak twist velocity and peak untwist velocity in the basal level had no remarkable changes( P > 0. 05). In contrast,peak rotate angle,peak twist velocity and peak untwist velocity in the apical level was significantly lower in the acute myocardial ischemia group after surgery than before,and it was significantly lower than in the control group after the sham operation( all P < 0. 05). Similar results were obtained for global rotate angle,global twist velocity,and global untwist velocity of left ventricular. Conclusions Systolic twist and diastolic untwist decreased after myocardial ischemia,which was mainly caused by changes at apical level. VVI can accurately measure minor alterations in left ventricular twist of a rabbit model of acute myocardial ischemia. These findings suggest that VVI may provide a reliable,noninvasive quantitative tool for early diagnosis of acute myocardial ischemia.

关 键 词：速度向量成像 急性心肌缺血 左心室扭转 

分 类 号：R542.2[医药卫生—心血管疾病] R445.1[医药卫生—内科学]