Cidec研究进展  

The Research Progress of Cidec

作　　者：郭冬妹[1] 江渝[1] 

机构地区：[1]第三军医大学基础部生物化学与分子生物学教研室,重庆市400038

出　　处：《中国动脉硬化杂志》2015年第1期101-104,共4页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金面上项目(81270363;81070288)资助

摘　　要：诱导细胞死亡的DFF45样效应因子C(Cidec)又名脂肪特异性蛋白27(FSP27),最先在小鼠脂肪细胞中分离得到,随后在人肝细胞、脂肪细胞等细胞中相继发现,属于Cide家族。研究发现,Cidec蛋白可定位于脂肪细胞的脂滴表面,促进脂肪的储存和脂滴体积的增大,进而调节脂肪代谢和机体能量平衡。Cidec在细胞凋亡方面也发挥着重要作用。Cell death-inducing DNA fragmentation factor 45-like C,also called fat specific protein 27,was firstly found in mouse adipocytes,subsequently found in human liver cells,fat cells and other cells,which belongs to the Cide family. The study has reported that Cidec can promote fat storage and increase lipid droplet volume by locating on the lipid droplet surface,further regulate fat metabolism and the energy balance. Cidec can also play an important role in apoptosis.

关 键 词：Cidec(FSP27) 脂代谢 脂滴 细胞凋亡 

分 类 号：R3416[医药卫生—基础医学]