凉血通瘀方对脑缺血大鼠血液系统及脑损伤的影响  

Effects of liangxuetongyu on hematological system and brain injury after cerebral ischemia in rats

作　　者：蒋宝平[1] 田磊[2] 许立[1] 

机构地区：[1]南京中医药大学,江苏南京210023 [2]南京中医药大学附属医院

出　　处：《中国老年学杂志》2015年第1期134-136,共3页Chinese Journal of Gerontology

基　　金：国家自然科学基金青年基金(81102885);江苏省自然科学基金(No.BK2007242);国家973计划(2006CB504807);江苏省高校优势学科建设工程资助项目(2014年)

摘　　要：目的探讨凉血通瘀方对实验性脑缺血大鼠血液系统及脑损伤的影响。方法采用插线阻断大鼠脑中动脉法制备脑缺血模型,观察凉血通瘀方低、中、高剂量对脑缺血模型大鼠的行为学评分、脑梗死率,血浆中活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB),血清中组织型纤溶酶原激活剂(t-PA)、纤溶酶原激活物抑制因子(PAI)-1、β血小板球蛋白(TG)、血小板因子(PF)4等指标的影响。结果凉血通瘀方中、高剂量能减轻模型大鼠脑损伤;延长血浆APTT、PT、TT,降低血浆中FIB含量;增加血清中t-PA含量,降低血清中PAI-1、β-TG、PF4含量。结论凉血通瘀方能改善脑缺血大鼠凝血-抗凝血-纤溶系统功能,减轻缺血引起的脑损伤。Objective To investigate the effects of liangxuetongyu on hematological system and brain injury after cerebral ischemia in rats. Methods The model was reproduced by middle cerebral artery occlusion( MCAO). The following indexes including behavior grade,ratio of cerebral ischemia,the contents of activated partial thromboplastin time( APTT),prothrombin time( PT),thrombin time( TT) and fibrinogen( FIB) content in plasma,contents of tissue-type plasminogen activator( t-PA),plasminogen activator inhibitor-1( PAI-1),betathromboglobulin( β-TG),platelet factor 4( PF4) in serum were evaluated after administrated with liangxuetongyu. Results Liangxuetongyu significantly decreased the injury of cerebral ischemia,prolonged APTT,TT,PT and decreased FIB content in plasma,increased t-PA and decreased PAI-1,β-TG,PF4 contents in serum. Conclusions Liangxuetongyu could improve coagulation and anticoagulant and fibrinolytic system and protect the damaged brain.

关 键 词：凉血通瘀方 脑缺血 凝血系统 

分 类 号：R285.5[医药卫生—中药学]