脂肪分化相关信号通路及microRNA调节研究进展  

Research Progress in Signaling Pathways and microRNA Regulation of Adipocyte Differentiation

作　　者：贾夏丽[1] 潘洋洋[1] 乔利英[1] 郭云雁[1] 胡子乔 张方[1] 李宝钧[1] 刘文忠[1] 

机构地区：[1]山西农业大学动物科技学院,太谷030801

出　　处：《畜牧兽医学报》2015年第4期518-525,共8页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金项目(31372292);山西省研究生优秀创新项目(20143059)

摘　　要：畜禽体内脂肪含量的多少决定了其肉质的好坏,而脂肪分化则是一个由许多因子调控的复杂生物学过程。了解脂肪分化相关的信号通路及其miRNAs的调节作用,可以在一定程度上揭示脂肪分化的分子调控机制。本文在对6个重要的调控脂肪细胞分化的信号通路进行介绍的基础上,分别对8个促进脂肪细胞分化和8个抑制脂肪细胞分化的miRNAs的生物学功能和作用机制进行了探讨,总结了其靶基因在脂肪形成中的作用。有关miRNAs及其靶基因的研究为畜禽肉质性状的遗传改良提供了理论依据。Content of body fat in domestic livestocks and poultry determines the meat quality.Adipocyte differentiation is a complex biological process regulated by many factors.Understanding the adipose differentiation-related signaling pathways and their miRNA regulations can reveal the molecular mechanisms of adipocyte differentiation.Based on introduction to the 6important signaling pathways regulating adipocyte differentiation,biological functions and mechanisms of 8miRNAs for promoting and another 8miRNAs for inhibiting adipocyte differentiation were discussed.The function of target genes of these miRNAs in adipogenesis was summarized.Studies on the related miRNAs and their target genes provide theoretical bases for genetic improvement of meat quality traits in domestic livestocks and poultry.

关 键 词：脂肪细胞 成脂分化 信号通路 MICRORNA 靶基因 

分 类 号：S813[农业科学—畜牧学]