乌鲁木齐市维吾尔族、汉族住院患者胰岛素抵抗状态下多种危险因素分析  

Study of the Risk Factors of the Uygur and the Hans with Insulin Resistance in Hospital of Urumqi

作　　者：楚新梅[1,2] 何秉贤[3] 吴永健 雷建新[5] 

机构地区：[1]北京市海淀医院 [2]北京大学第三医院海淀院区心内科,北京市100080 [3]新疆医科大学第一附属医院心血管病研究所,新疆乌鲁木齐市830054 [4]阜外心血管医院冠心病中心,北京市100037 [5]新疆维吾尔自治区人民医院心内科,新疆乌鲁木齐市830001

出　　处：《中国动脉硬化杂志》2015年第3期281-284,共4页Chinese Journal of Arteriosclerosis

基　　金：新疆自治区卫生厅青年科技人才专项基金(新卫科青字2001Y04)

摘　　要：目的探讨乌鲁木齐市住院患者维吾尔族和汉族胰岛素抵抗(IR)状态下多种危险因素分布特点。方法来自内科住院病人219例,均进行葡萄糖糖耐量试验和胰岛素释放试验,运用稳态模式法评价胰岛素抵抗对维吾尔族、汉族多种危险因素分布的影响。结果维吾尔族胰岛素抵抗组体重和腰臀比大于维吾尔族对照组,差异有统计学意义(P<0.05);汉族胰岛素抵抗组总胆固醇(TC)和低密度脂蛋白(LDLC)高于汉族对照组,差异有统计学意义(P<0.05)。维吾尔族胰岛素抵抗组体重、体质指数(BMI)和腰围大于汉族胰岛素抵抗组,差异有统计学意义(P<0.05)。维吾尔族体质指数明显高于汉族人群,即非胰岛素抵抗组维吾尔族高于汉族(26.84±4.19 vs25.52±3.19)kg/m2,(P<0.05),胰岛素抵抗组维吾尔族高于汉族(27.77±3.60 vs 26.09±3.68)kg/m2(P<0.05)。多个危险因素(Logistic回归分析)分析发现糖尿病、高血压、总胆固醇和甘油三酯与胰岛素抵抗呈正相关(P<0.01)。高密度脂蛋白(HDLC)与胰岛素抵抗呈负相关(P<0.01)。结论在乌鲁木齐市住院患者胰岛素抵抗人群中,维吾尔族以肥胖为主,汉族以胆固醇升高为主。糖尿病、高血压和血脂异常与胰岛素抵抗密切相关。Aim To explore the prevalence of the cluster of cardiovascular risk factors in the races of the Uygur and the Hans in hospital with insulin resistance( IR) in Urumqi. Methods Oral glucose tolerance test( OGTT) and insulin release test were used to measure concentration of blood glucose and insulin before and after oral 75 g glucose in 0h,0. 5 h,1 h,2 h and 3 h,which were recorded in 219 subjects in hospital. Insulin resistance( HOMA IR) were calculated by Homeostasis model assessment( the Homa model). Results In the insulin resistance subjects,the Uygur increased significantly in weight and waist-to-hip ratio compared with the controls,whereas the Hans mainly showed the elevated total cholesterol( TC) and low-density lipoprotein cholesterol( LDLC) compared with the controls( P < 0. 05). The Uygur increased significantly in weight,body mass index( BMI) and waist circumference compared with the Hans in the insulin resistance subjects( P < 0. 05). The Uygur increased significantly in body mass index compared with the Hans,the controls( 26. 84 ± 4. 19 kg / m2 vs 25. 52 ± 3. 19 kg / m2) and the insulin resistance subjects( 27. 77 ± 3. 60 kg/m2 vs 26. 09± 3. 68 kg / m2; P < 0. 05). Diabetes mellitus,hypertension,TC,and triglyceride( TG) had positive correlation with IR( P < 0. 01); and high density lipoprotein cholesterol( HDLC) had negative correlation with IR by Logistic Regression( P <0. 01). Conclusion The Uygur had more obesity and the Hans had higher cholesterol in the population with insulin resistance in Hospital,Urumqi. Diabetes mellitus,hypertension and dyslipidemia were closely related to IR.

关 键 词：维吾尔族 汉族 胰岛素抵抗 体质指数 胆固醇 

分 类 号：R587.1[医药卫生—内分泌]