瑞舒伐他汀对慢性心力衰竭合并阵发性心房颤动的疗效观察  

The Clinical Effects of Rosuvastatin for Chronic Heart Failure with Paroxysmal Atrial Fibrillation

作　　者：剡冬冬 马凌[1] 张卫泽[1] 王菲[1] 郭文韵 蔡小庆[1] 史亮[1] 

机构地区：[1]兰州军区兰州总医院心内科,甘肃省兰州市730050

出　　处：《中国动脉硬化杂志》2015年第4期407-410,共4页Chinese Journal of Arteriosclerosis

摘　　要：目的观察瑞舒伐他汀降脂之外对慢性心力衰竭合并阵发性心房颤动患者C反应蛋白(CRP)、白细胞介素6(IL-6)、脑钠尿肽(BNP)、左心室射血分数(LVEF)、左心房内径(LAD)、窦律维持及卒中的影响。方法 98例慢性心力衰竭合并阵发性心房颤动患者,在常规抗心衰治疗的基础上分为瑞舒伐他汀组(50例)和对照组(48例)。比较两组患者治疗前后、出院第1、12月CRP、IL-6、BNP、LVEF、LAD的变化,以及阵发性心房颤动再发、永久性心房颤动发生、心衰再住院及卒中发生的差别。结果与对照组比较,瑞舒伐他汀组在长期治疗后CRP、IL-6水平明显降低,LAD缩小,阵发性心房颤动再发、永久性心房颤动及卒中的发生均降低,LVEF、BNP及心衰再住院率两组之间差异无显著性。结论瑞舒伐他汀除降脂外,可降低慢性心力衰竭合并阵发性心房颤动患者的炎症水平,抑制心房重构,减少阵发性心房颤动的发作,但对左心室收缩功能无改善。Aim To observe the effect of rosuvastatin on C-reaction protein(CRP),interleukin-6(IL-6),brain natriuretic peptide( BNP),left ventricular ejection fraction( LVEF),left atrial diameter( LAD) and sinus rhythm maintenance in patients of the heart failure with paroxysmal atrial fibrillation. Methods All of 98 patients of chronic heart failure( CHF) with paroxysmal atrial fibrillation were converted to sinus rhythm after treatment. They were divided into rosuvastatin group(50 patinets) and control group(48 patinets) on the basis of routine CHF treatment. After follow-up12 months,the change of CRP,IL-6,BNP,LVEF,LAD,the rate of recurrence of atrial fibrillation,incidence rate of heart failure were compared in two groups before and after treatment and the first and the twelfth month after discharge.Results Compared with control group,the level of CRP and IL-6 were significantly reduced,and LAD shrinked,the rate of recurrence of permanent atrial fibrillation and rehospitalization were reduced in rosuvastatin group. The cardiac function had no obvious improvement in control group and rosuvastatin group. Conclusions Rosuvastatin can reduce the level of chronic inflammation in the heart failure patients with paroxysmal atrial fibrillation and inhibit atrial remodeling,reduce the recurrence of paroxysmal atrial fibrillation,but had no obvious improvement to left ventricular systolic function.

关 键 词：瑞舒伐他汀 心力衰竭 心房颤动 炎症因子 

分 类 号：R541.75[医药卫生—心血管疾病] R541.6[医药卫生—内科学]