巴比妥与4-乙烯基吡啶分子印迹聚合物的设计及性能评价  

Design and Properties of Barbital Imprinting System with 4-Vinylpyridine as Functional Monomer

作　　者：苏婷婷[1] 刘俊渤[1] 唐珊珊[1] 靳瑞发[2] 

机构地区：[1]吉林农业大学资源与环境学院,吉林长春130118 [2]内蒙古赤峰学院化学化工学院,内蒙古赤峰024000

出　　处：《高分子材料科学与工程》2015年第2期5-10,共6页Polymer Materials Science & Engineering

基　　金：国家自然科学基金资助项目(21302062);吉林省科技厅发展计划项目(20150101018JC);吉林省教育厅科学技术项目(201359);吉林省科技发展计划项目(20130206099SF)

摘　　要：采用量子化学密度泛函理论(DFT)的M062X/6-31G(d,p)方法,模拟巴比妥(BAR)印迹分子与4-乙烯基吡啶(4-Vpy)功能单体的相互作用,确定BAR与4-Vpy的最佳印迹比例为1∶3。然后,在60℃乙腈中采用1∶3印迹比例合成巴比妥分子印迹聚合物(BAR-MIPs),并对BAR-MIPs微球形貌、印迹识别性能及选择性能等进行表征。结果表明,BARMIPs为微球形状,粒径在120~390 nm之间;Scatchard分析表明,在研究的浓度范围内MIPs对模板BAR的结合位点是等价的,其离解平衡常数(Kd)与最大表观结合量(Qmax)分别为29.1 mg/L和13.1 mg/g;BAR-MIPs对BAR的吸附量明显高于其对1,3-二甲基巴比妥酸(DMBA)、2-硫代巴比妥酸(TMB)及戊巴比妥钠(PBS)的吸附量,表现出较强的特异性吸附能力。The simulation of interaction processes between barbital(BAR) and 4-vinylpyridine(4-Vpy) were performed basing on the density functional theory of M062 X /6-31G(d,p). The excellent imprinting ratio is 1∶ 3 between BAR and 4-Vpy. The BAR molecular imprinted polymer microspheres(BAR-MIPs) were synthesized by precipitation polymerization. The SEM photographs,the adsorption efficiency,and FT-IR were employed to demonstrate the particle size distribution,properties,and the mechanism of interaction. The experimental results indicate that the diameter of BAR-MIPs is ranging from 120 nm to 390 nm. Analysis of the Scatchard plot reveals that the binding sites of BAR-MIPs to BAR are equal class within the studied concentration range,and the dissociation constant(Kd) and apparent maximum adsorption quantity(Qmax) of BAR-MIPs are 29. 1 mg /L and 13. 1 mg /g,respectively. The study of selective adsorption shows that BAR-MIPs has higher selectivity for BAR than for 1,3-dimethyl barbituric acid(DMBA),2-thiobarbituric acid(TMB),and pelltobarbitalum natricum(PBS).

关 键 词：巴比妥 4-乙烯吡啶 分子印迹聚合物 模拟 吸附量 

分 类 号：O631.3[理学—高分子化学]