吗啉-2,5-二酮衍生物及其聚合物的研究进展  

Progress in Morpholine-2,5-Dione Derivatives and their Copolymers

作　　者：于丽[1] 冯亚凯[1] 石常灿 郝雪芳 

机构地区：[1]天津大学化工学院,天津化学化工协同创新中心,天津300072

出　　处：《高分子通报》2015年第3期18-25,共8页Polymer Bulletin

基　　金：国家自然科学基金(31370969);国家教育部博士点专项基金(20120032110073);科技部国家国际合作(2013DFG52040)

摘　　要：吗啉-2,5-二酮衍生物是一类制备可生物降解材料的环状单体,本文综述了吗啉-2,5-二酮衍生物及其聚合物的合成方法,以及其在生物医用领域的应用前景。首先介绍了吗啉-2,5-二酮衍生物的三种合成方法,以及采用吗啉-2,5-二酮衍生物均聚反应制备聚缩肽的方法,其次介绍了吗啉-2,5-二酮衍生物与ε-己内酯和丙交酯开环共聚制备基于氨基酸的共聚物。最后,总结了吗啉-2,5-二酮衍生物嵌段共聚物的制备,及其在药物释放和基因载体应用研究中的最新进展。Morpholine-2,5-dione derivatives are a kind of cyclic monomers for the preparation of biodegradable materials.This paper summarized the synthesis methods of morpholine-2,5-dione derivatives and their copolymers,as well as their potential applications in medical field.Firstly,three synthesis methods of these derivatives were introduced,also the homopolymerization of morpholine-2,5-dione derivatives to prepare polydepsipeptides was summarized.Secondly,this paper introduced ring-opening copolymerization of morpholine-2,5-dione derivatives with e-caprolactone and lactide to prepare the copolymers based on amino acids.Finally,this paper summarized the synthesis of morpholine-2,5-dione derivatives block copolymers,and the recent development of their applications in drug delivery and gene carriers.

关 键 词：吗啉-2 5-二酮衍生物 生物降解 开环共聚 医用材料 

分 类 号：O633.5[理学—高分子化学]