子宫内膜异位蛋白质(ENDO-1)在内异症组织的表达及其临床意义  

Expression of ENDO-1(haptoglobin) in the ectopic and eutopic endometrium of women with endometriosis

作　　者：刘荣华[1] 黄婉[2] 

机构地区：[1]广州医学院2001级 [2]广州医学院附属妇婴医院妇二区,广东广州510080

出　　处：《国际医药卫生导报》2004年第12期26-29,共4页International Medicine and Health Guidance News

摘　　要：目的 探讨子宫内膜异位蛋白质(ENDO-1)在子宫内膜异位症内的表达及其意义。方法 采用逆转录—多聚合酶反应(RT-PCR)方法检测两组组织中子宫内膜异位蛋白质(ENDO-1)的阳性表达情况。研究组为20例配对的内异症患者(异位灶及在位内膜),对照组为15例无异位症患者的在位内膜。结果 研究组20例显示:在内异症的异位病灶内这种物质在黄体期内的表达有明显的差异性(p=0.004)。研究组患者黄体期的在位内膜与对照组相比,后者表达水平较低(p=0.04),差异有显著性。结论 因此ENDO-1在诊断内异位方面可能是一个特异性的标志物,对异位症的发病机制方面,尤其是免疫机理,可以对之作出较好的解释,同时也为内异症的治疗提供一个新的方向。Objective To detect the expression of the ENDO-1(haptoglobin) in the ectopic andeutopic endometrium of women with endometriosis。Methods A reverse transcription-polymerse reaction(PC-PCR) mothod was utilized to examine Endo-1 mRNA expressions in eutopic and autopic endometrium。Twenty patients with endometriosis were included as study group,and fifteen patients without en-dometriosis selected as control group。Results In 20 matched endometrial and endometriosis specimensExpression(p=1.00) was similar in matched progestational stage endometrium and endometriosis,butendometriotic expression (p=0.004) were significantly greater in secretory 。Eutopic endometrium ofwomen with endometriosis has a higher level of ENDO-1mRNA than women without endometriois(p=0.04)。Conclusions The ENDO-1 mRNA is over expressed in progestational stage endometriosis。Haptoglobin-like ENDO-1 may be associated with localized angiogenesis and altered immune response involved with theaetilogy/pathhphysiology of endometriosis。

关 键 词：子宫内膜异位症 子宫内膜异位蛋白 在位内膜 异位内膜 

分 类 号：R711.71[医药卫生—妇产科学]