巯基乙酸甲酯的合成研究  

The Synthesis of Methyl - mercaptoacetate

作　　者：林昌志[1] 

机构地区：[1]安徽丰乐农化有限责任公司,合肥230031

出　　处：《安徽化工》2004年第3期26-27,共2页Anhui Chemical Industry

摘　　要：在催化剂A的作用下,选用巯基乙酸与甲醇经分子间脱水缩合反应获得巯基乙酸甲酯.研究了不同的摩尔比、反应温度、反应时问、催化剂用量等对产物巯基乙酸甲酯收率的影响.实验表明:催化剂A的用量为巯基乙酸摩尔数的10%,甲醇与巯基乙酸的摩尔比为1 2:1,反应时间为8小时,反应温度为38～40℃时,合成的巯基乙酸甲酯收率达到85%以上.In this paper the method to obtain the methyl-mercaptoacetate is introduced by the andensation action of the mercaptoacetic acid and methanol,which the catalyst A is used.The paper also discussed the various effects (such as the different mol ratio,reaction temperture,reaction time and catalyst's amount ) on the yield of methyl-mercaptoacetate.The results showed that the used amount of catalyst A should be equal to 10% mol amount of mercaptoacetic acid,the mol ratio of methanol and mercaptoacetic acid 1.2:1,the reaction time 8 hr,the reaction tempeture 38～40℃,thus the synthesis yield will reach over 85%.

关 键 词：巯基乙酸甲酯 合成 巯基乙酸 甲醇 分子间脱水缩合 产率 工艺参数 

分 类 号：TQ225.27[化学工程—有机化工]