白介素 -2的抗炎作用和免疫调节作用(英文)  

Anti-inflammatory Effects and Immunomodulatory Effects of Interleukin-2

作　　者：汤玥[1] 朱家壁[1] 程度胜 张月[1] 曹斯琦[1] 周波[1] 

机构地区：[1]中国药科大学药物制剂研究所,江苏南京210009 [2]北京四环生物制药有限公司,北京100071

出　　处：《药物生物技术》2004年第3期173-177,共5页Pharmaceutical Biotechnology

摘　　要：研究重组人白介素 2 (rhIL 2 )的抗炎和免疫调节作用。选择小鼠鼠耳肿胀和大鼠足拓肿胀模型研究rhIL 2的抗炎作用 ;选择碳廓清率实验、迟发性变态反应实验研究rhIL 2的免疫调节作用。RhIL 2注射液 ,剂量为 2 0 ,10 ,5,2 .5,1.2 5万u/kg时 ,对小鼠鼠耳肿胀模型有抑制作用 ,其中剂量为 2 .5～ 5万u/kg时 ,抑制率最大 ;剂量为 2 .5万u/kg时 ,对大鼠足拓肿胀模型有显著的抑制作用 ;rhIL 2注射液每日sc用药剂量为 10万u/kg ,连续给药 9d后 ,可以明显增强小鼠单核吞噬细胞功能 ;rhIL 2注射液每日sc用药剂量为 5万u/kg ,连续给药 6d后 ,可明显减轻由免疫抑制剂引起的小鼠迟发性变态反应降低的强度。rhILTo study anti-inflammatory effects and immunomodulatory effects of Interleukin-2(IL-2). Mouse ear swelling and rat plantar swelling were used as animal models of anti-inflammatory efficacy. Immunomodulatory effects were studied by carbon clearunce and delayed hypersensitivity reaction in mice. Injection of rhIL-2 (200,100,50,25,12.5()ku/kg) can inhibit mouse ear swelling, especially when dosage is 25～50()ku/kg. Injection of rhIL-2 ((25()ku/kg)) can inhibit rat plantar swelling. The function of mononuclear macrophage system was strengthened by hypodermic injection of rhIL-2(100()ku/kg) once a day for 9 days. The decrease of mouse (delayed-type) hypersensitivity reaction induced by cyclophosphamide was extenuated by hypodermic injection of rhIL-2(50()ku/kg) once a day for 6 days. IL-2 has anti-inflammatory effects and immunomodulatory effects when administered in certain dosage.

关 键 词：白介素-2 抗炎 免疫调节 整体模型 

分 类 号：R965[医药卫生—药理学]