医药级结晶麦芽糖的试制  

Study on Preparation of Pharmaceutical Grade Crystalline Maltose

作　　者：徐以撒[1] 周国平[1] 杨柳新[1] 

机构地区：[1]江苏工业学院化工系,江苏常州213016

出　　处：《药物生物技术》2004年第3期178-180,共3页Pharmaceutical Biotechnology

摘　　要：参照日本药典中结晶麦芽糖的主要质量指标 ,研究了高纯度结晶麦芽糖的制备过程。薯类淀粉液化到低葡萄糖值 ,3种酶复合糖化 ,经过脱色、脱盐精制 ,色谱分离除去糊精 ,浓缩后运动降温结晶 ,过滤除去母液 ,烘干即得结晶麦芽糖成品。The preparation of high purity crystalline maltose was studied following the quality requirements specified in the Japanese Pharmacopeia. Potato or cassava starch was liquefied to low DE, followed by 3-amylases saccharification. Then purified by active carbon and ion-exchange, followed by a chromatographic process to get rid of maltodextrin. The refined syrup was then vacuum vaporized, dynamically crystallized at declining temperatures, followed by separation from mother liquor and dried. Crystalline maltose thus obtained was proved with HPLC to march the Pharmacopeia standard.

关 键 词：医药级 结晶麦芽糖 色谱分离 运动降温结晶 

分 类 号：Q539[生物学—生物化学]