健脾消痞浸膏对脾虚大鼠胃分泌影响的实验研究  

Effects of Jianpi Xiaopi extract on gastric secretion of spleen deficiency rats

作　　者：陈勇鹏[1] 陆萌[2] 晋献春[1] 王志坦[3] 

机构地区：[1]第三军医大学新桥医院中医科,重庆400037 [2]第三军医大学西南医院眼科,重庆400038 [3]第三军医大学成都中医药大学中医内科学教研室,成都610075

出　　处：《第三军医大学学报》2004年第12期1108-1110,共3页Journal of Third Military Medical University

摘　　要：目的　观察健脾消痞浸膏对脾虚大鼠胃分泌的影响。方法　用大黄水煎剂造脾虚动物模型 ,用滴定法测定胃液分泌 ,用放射免疫法测定血浆胃泌素。结果　与脾虚模型组比较 ,健脾消痞浸膏中剂量组总酸度、总酸排出量升高 (P<0 .0 5 ) ,高剂量组胃液量、总酸度、总酸排出量均显著升高 (P <0 .0 1)。中、高剂量组血浆胃泌素显著升高 (P <0 .0 1)。Objective To observe the effects of Jianpi Xiaopi extract on gastric secretion of experimental SD rats with spleen deficiency. Methods Animal model of spleen deficiency was established by using Rhubarb decoction. The gastric secretion was determined by titration method, and the gastrin in plasma was measured by radioimmunoassay. Results Compared with those in spleen deficiency group, the levels of the total acidity and the output of total acid were higher in the middle dose group treated with Jianpi Xiaopi extract ( P <0.05). The levels of the gastric juice, total acidity, and output of total acid were significantly higher in the high dose group ( P <0.01). The gastrin in plasma was significantly higher in the middle and high dose groups treated with Jianpi Xiaopi extract ( P <0 01). Conclusion Jianpi Xiaopi extract can stimulate gastric secretion and increase gastrin in plasma of rats with spleen deficiency.

关 键 词：健脾消痞浸膏 脾虚大鼠 胃分泌 胃泌素 

分 类 号：R256.39[医药卫生—中医内科学] R289.5[医药卫生—中医学]