不同基质对全缘千里光碱凝胶剂体外释放和透皮特性的影响  

Influence of gel vehicles on release in vitro and transdermal resorption of integerrimine

作　　者：徐月红[1] 徐莲英[2] 蔡定国[3] 陈宝[1] 何岚 

机构地区：[1]中山大学药学院药剂实验室,广东广州510080 [2]上海中医药大学药剂教研室,上海200032 [3]海军411医院,上海200081

出　　处：《中成药》2004年第6期444-446,共3页Chinese Traditional Patent Medicine

基　　金：上海市科委科技攻关 0 2DZ1912 1

摘　　要：目的 :通过体外释放和透皮实验 ,优选全缘千里光碱凝胶剂基质 ,为制备全缘千里光碱透皮给药抗肿瘤的新制剂提供参考。方法 :利用溶出仪建立体外释放实验 ,体外透皮采用改良的Franz扩散池法 ,并通过RP HPLC法测定释放液和接收液中全缘千里光碱的含量。结果 :全缘千里光碱三种基质的凝胶体外释放符合Higuchi方程 ,释放速率CMC Na凝胶 >HPMC凝胶 >Carbopol凝胶。体外透皮符合零级动力学过程 ,稳态透皮速率HPMC凝胶 >CMC Na凝胶 >Carbopol凝胶。结论 :凝胶剂作为全缘千里光碱透皮吸收新剂型是可行的 ,首选HPMC作为凝胶基质 ,不宜选择Carbopol作基质。AIM: The gel vehicle was optimized by release and transdermal resorption of integerrimine in vitro in order to design its anti-cancer transdermal drug delivery system. METHODS: The releasing rate was detected by dissolution Vilia-Chien diffusion cells, nude mouse skin were used as permeation barrier, the concentration of integerrimine in samples was measured by RP-HPLC. RESULTS: Integerrimine releases of three different vehicles conformed to Higuchi equation, the releasing rate of CMC-Na gel is faster than that of HPMC gel, and that of Carbopol gel is the slowest in three, and corresponded with zero kinetic equation. CONCLUSION: HPMC is an drug vehicle of choice.

关 键 词：全缘千里光碱 峨眉千里光 凝胶剂 透皮吸收 体外释放 裸鼠 

分 类 号：R944[医药卫生—药剂学]