右心室流出道电生理特性及临床意义  

Electrophysiological Characteristics of Guinea-pig Right Ventricular Outflow Tract and Its Clinical Significance

作　　者：陈彦静[1] 马建伟[1] 张晓云[1] 焦宏[1] 黄志敏 李建东[3] 

机构地区：[1]张家口医学院生理教研室,075000 [2]河北省沽源县妇幼保 [3]张家口医学院生理教健院

出　　处：《张家口医学院学报》2004年第3期3-5,共3页

基　　金：河北省自然科学基金资助项目 (No30 0 379)

摘　　要：目的 :研究右心室流出道的电生理特性 ,并探讨其与心室流出道心律失常的关系。方法 :利用细胞内微电极记录技术 ,观察豚鼠右心室流出道组织的电活动特性。结果 :在 2 3例豚鼠右室流出道组织标本中 4例 ( 17.39% )可记录到自律性电活动。在紧靠瓣膜下及流出道光滑部的局部区域可记录到非自律性慢反应电位 (MDP :6 2 .2 8± 8.14mv ,APA :6 5 .2 2± 15 .18mV ,Vmax :2 2 .2 7± 8.13v/s,APD90 :176 .2 4± 10 .13ms ,APD5 0 :12 3.4 7± 12 .36ms)及形态不典型的自律性慢反应电位 ,其 0相去极化速度、幅度及动作电位时程变异较大。大部分区域为非自律快反应动作电位 (MDP :71.2 3± 6 .6 2mv ,APA :79.33± 5 .4 8mV ,Vmax :10 3.13± 9.0 3v/s,APD90 :16 6 .2 3± 2 0 .33ms ,APD5 0 :12 6 .33± 16 .2 6ms) ,其特征与普通心室肌细胞动作电位相似。结论 :右心室流出道组织的电生理特性与普通心室肌不同 ,其自律性和电生理异质性可能是某些流出道心律失常的电生理学基础。Objective:To study the electrophysiological characteristics of right ventricular outflow tract(RVOT) and its Clinical Significance. Methods:Action potentials of RVOT in 23 Guinea-pig preparations were recorded using intracellular microelectrode technique. Results: Spontaneous activity could be recorded in 4 preparations(17.39%). no-spontaneous slow action potentials could recorded from local areas of RVOT(MDP: 62.28±8.14mv, APA: 65.22±15.18mV, Vmax: 22.27±8.13v/s, APD90:176.24±10.13ms, APD50: 123.47±12.3 6ms) , it showed a slow rising phase but no marked spontaneous depolarization in phase 4; Fast action potentials recorded from most regions of RVOT(MDP:71.23±6.62mv,APA:79.33±5.48mV,Vmax:103.13±9.03v/s,APD90:166.23±20.33ms, APD50:126.33±16.26ms).Conclusion:The result indicates that Guinea-pig right ventricular outflow tract possessing automaticity and electrophysiological heterogeneity, and these may be applied to interpret ventricular outflow tract arrhythmia .

关 键 词：右心室流出道 电位 心律失常 电生理异质性 自律性 

分 类 号：R540.4[医药卫生—心血管疾病]