利培酮、氯氮平对血糖、血脂影响的研究  

Effect of risperdane and clozaine on the blood surga and blood fat in patients with schizophenis

作　　者：孙东[1] 江琴普[1] 苏顺英[1] 刘杰[1] 栗克清[1] 李建峰[1] 

机构地区：[1]河北省精神卫生中心,河北保定071000

出　　处：《河北职工医学院学报》2004年第2期8-10,共3页Journal of Hebei Medical College for Continuing Education

摘　　要：目的了解非典型抗精神病药利培酮、氯氮平对精神分裂症患者血糖、血脂的影响。方法随机抽取2002年6月1日 -2003年6月1日间在河北省精神卫生中心住院、年龄18～65岁、符合CCMD -3精神分裂症诊断标准、分别接受利培酮、氯氮平治疗的100例患者 ,用自制调查表进行调查患者治疗前后血糖、血脂的变化 ,用BPRS评定疗效。结果服用利培酮、氯氮平治疗的100例精神分裂症患者基线时血糖、血胆固醇、甘油三脂无显著差异。治疗4周、8周、12周后患者血胆固醇、甘油三脂均明显升高(P<0.05)。两组进行比较 ,治疗12周后 ,氯氮平组空腹血糖明显高于利培酮治疗组(P<0.05)。结论非典型抗精神病药物利培酮、氯氮平可能会引血胆固醇、甘油三脂的升高 ,血糖变化不明显。氯氮平致血糖升高的风险大于利培酮 ,临床用药时应注意监测血糖、血脂的变化。Objective To study the changes of blood surga and blood fat after treating with atypical psychothpic drug-risperidone or cloxzapine in schizophrenics.Methods one hundred patients with schizophenia were treated with risperidone or clozapine who were selected randomly from Hebei Mental Health Center.(2002.6.1-2003.6.1)aged from18-65.Using home-made questionaire.Results The changes of blood surga,cholesterol(TC)triglyceride(TG)after treating with risperidone or clozapˉine in one hundred patients with schizophrenia were significantly different in statistics(P<0.05).Con_ clusions The atypical psychotropic drugs such as risperidone and clozapine can cause blood surga cholesterol(TC)triglyceride(TG)rise.We should pay attention to the changes of blood surga and blood fat when using atypical psychotropic drugs in clinical practices.

关 键 词：利培酮 氯氮平 血糖 血脂 精神分裂症 抗精神病药 

分 类 号：R971.4[医药卫生—药品]